Abortion, Missed
Conditions
Brief summary
Second trimester abortion can be done surgically or medically. Medical abortion with mifepristone and misopristol is one of the common protocol, but misopristol have high rate side effect. The investigators recent study proved the efficacy of pitocin after mifepristone in second trimester abortion with minimal side effects. Working hypothesis and aims: To compare misopristol and pitocin after mifepristone preparation in second trimester in seccess rate, interval to abortion, side effects and patient satisfaction.
Interventions
DRUGmifepristone and misopristol
200 mg mifepristone and after 48 hours vaginal misopristol 800 mgr followed by oral misopristol 400 mgr every 3 hours for maxamum 5 doses
DRUGmifepristone and oxytocin
200 mg mifepristone followed 48 hours with high dose oxytocin drip (9 unit per hour)
Sponsors
Hadassah Medical Organization
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* midtrimester late abortion * midtrimester induced abortion
Exclusion criteria
* placenta previa * infected abortion * rupture of membranes * s/p cesarean section \*2 or more
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of abortion | 24 hours |
| Interval to abortion | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| Side effects | 24 hours |
Countries
Israel
Outcome results
None listed