Visceral Pain From the Upper Urinary Tract - a Trial on the Effect of Morphine and Oxycodone in Patients Undergoing PCNL

Visceral Pain Originating From the Upper Urinary Tract - a Randomized Controlled Trial on the Effect of Morphine and Oxycodone in Patients Undergoing Percutaneous Nephrolithotomy (PCNL)

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00784472

Enrollment

Registered

2008-11-04

Start date

2008-12-31

Completion date

2012-06-30

Last updated

2012-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Stones

Keywords

PCNL, oxycodone, morphine, visceral pain

Brief summary

The purpose of this study is to investigate the effect of oxynorm versus morphine after operation for kidney stone (PCNL). In addition the relationship between pain symptoms and referred sensory and trophic changes will be examined in the patients before and after the operation.Finally a blood sample is analysed to investigate pharmaca-genetics.

Detailed description

Primary outcome: the amount of opioid (morphine or oxynorm) used the first 4 hours postoperatively. Secondary outcome: side effect to the opioids, pain score, pain threshold to electrical stimulation and pressure before and after operation, pharmacogenetics, size of referred pain area.

Interventions

DRUGoxycodone

intravenous according to patients weight, pn.

DRUGmorphine

intravenous administration according to patients weight, pn.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 * Indication for PCNL

Exclusion criteria

* Malignant disease in the upper urinary tract * Allergy to morphine or oxycodone * Use of opioids the last 48 hours before PCNL * Pregnancy * Nursing mothers * Present JJ-stent in the ureter * Previous urinary stone disease on the opposite site

Design outcomes

Primary

Measure	Time frame
Amount of analgetics used	four hours postoperatively

Secondary

Measure	Time frame
Side effects	four hours postoperatively

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026