Diabetes, Prediabetes
Conditions
Keywords
alcohol diabetes CVD
Brief summary
Moderate alcohol may be beneficial for diabetics
Interventions
DIETARY_SUPPLEMENTalcohol
150 cc
Sponsors
Ben-Gurion University of the Negev
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Established diagnosis of type 2 diabetes * Male or female alcohol abstainers (not more than 1 drink/week) * Age between 40-75 yrs * Clinically stable, with no history of stroke or myocardial infarction or major surgery within the previous 3 months
Exclusion criteria
* The use of RI or short-acting analog insulin/ pump therapy. Patients on 1-2 injections per day of NPH or long-acting analogs will be eligible for inclusion * Triglycerides \> 500 mg/dL * HbA1c\<7 or \> 10% * Serum creatinine \> 2 mg/dl * Liver dysfunction (greater than 2-fold elevation of ALT or and 3-fold elevation of AST) * Evidence of severe diabetes complications (such as proliferative retinopathy or overt nephropathy) * Autonomic neuropathy manifested as postural hypotension or hypoglycemia unawareness * Patients with chronic hepatitis (C,B) * Use of drugs that might significantly interact with alcohol such as sedatives, antihistamines, and anti-coagulants * Presence of active cancer, or chemotherapy within the past 3 years * Major illness that may require hospitalization * A high potential of addictive behavior based on physician's assessment or personal or family history of addiction, alcoholism, or alcohol abuse * Pregnant or lactating woman * Participation in another trial with active intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycemic control | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| CVD status | 6 months |
Outcome results
None listed