Idiopathic Pancreatitis
Conditions
Keywords
recurrence of idiopathic pancreatitis, laparoscopic cholecystectomy, etiology of pancreatitis
Brief summary
The causes of acute pancreatitis in Finland are alcohol overuse (60%), cholecystolithiasis (20%) and idiopathic (i.e. etiology unknown)(20%). Acute pancreatitis may recur in over half of cases and may be fatal in severe cases in 30%. Majority of idiopathic pancreatitis are caused by microlithiasis in gall bladder. The purpose of this randomized study is to prevent recurrence of idiopathic pancreatitis by performing laparoscopic cholecystectomy compared to non-operative group in 2 years follow-up of patients.
Detailed description
Etiologic investigations include serum amylase, lipase, triglyceride and calcium determination, as well as abdominal ultrasound scanning. Alcohol consumption is asked by using WHO audit test. After etiology of acute pancreatitis has been confirmed as idiopathic, 100 patients are randomized to laparoscopic cholecystectomy and 100 patients to follow-up of 2 years. Five to seven Finnish university and main central hospitals are participating the study.
Interventions
PROCEDURELaparoscopic cholecystectomy
Surgery
Sponsors
Kuopio University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* idiopathic pancreatitis
Exclusion criteria
* age \< 18 years old * patients' refusal * high operative risks * alcohol overuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| recurrence of acute pancreatitis | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| etiology of acute pancreatitis in Finland in 2009-10 | 2 years |
Countries
Finland
Contacts
Primary ContactHannu EK Paajanen, MD, PhD
Backup ContactSari Paajanen, MD, PhD
Outcome results
None listed