Breathing Patterns, Respiratory Insufficiency, Respiratory Physiology
Conditions
Keywords
breathing patterns,, unidirectional breathing,, mask ventilation,, respiratory physiology
Brief summary
Our aim in this study is to investigate the efficiency of the breathing with different breathing patterns. Ten volunteers and twenty patients having respiratory problems will be coached on their breathing through specific masks which will provide four different breathing patterns. These patterns will be 1) Breathing in through the nose only and out through the mouth only 2) Breathing in through the mouth only and out through the nose only 3) Breathing in and out through the nose only 4) Breathing in and out through the mouth only The data obtained from volunteers and patients will be compared within and between the groups.
Interventions
OTHERBreathing Patterns
All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following: 1. Breathing in through the nose only and out through the mouth only 2. Breathing in through the mouth only and out through the nose only 3. Breathing in and out through the nose only 4. Breathing in and out through the mouth only
Sponsors
Massachusetts General Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* For healthy subjects: 1\. Ten healthy adult (\> 18 years of age) volunteers will be recruited from the MGH main campus through intra-hospital e-mail broadcasting. Subjects with the following issues will be excluded from the study. * For patients with respiratory insufficiency: 1. Twenty adult (\> 18 years of age) patients will be recruited. These patients will be either patients in acute respiratory failure resulting from COPD exacerbation breathing spontaneously only receiving nasal oxygen admitted to the medical floors of the MGH; or patients with diagnosed stable COPD on home oxygen therapy seen by pulmonary physicians in the outpatient clinics or coming to the MGH as study subjects.
Exclusion criteria
* For healthy volunteers: 1. Subjects with facial deformity, heavy beard or moustache which prevents good seal between the mask and the face; 2. Subjects who have claustrophobia and cannot wear the mask. * For patients with respiratory insufficiency: 1. Patients with facial deformity, heavy beard or moustache which prevents a good seal between the mask and the face; 2. Patients who have claustrophobia and cannot wear the mask. 3. Patients who are hemodynamically unstable. 4. Patients requiring continuous noninvasive positive pressure ventilation or endotracheal intubation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determining the anatomic dead space change at variable tidal volumes with four different breathing patterns (nose-in and nose-out, mouth-in and mouth-out, nose-in and mouth-out, mouth-in and nose-out) in healthy volunteers. | 3 months |
| Comparing the efficiency of CO2 removal at given minute ventilations with the four different breathing patterns in patients with chronic respiratory failure. | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Comparing the efficiency of the study mask which forces subjects to breathe in a manner similar to pursed lip breathing and a regular facemask in healthy volunteers and patients with respiratory failure | 6 months |
Countries
United States
Outcome results
None listed