Peripheral Reservoir of HIV DNA in Monocytes Pivotal to Cognition in HIV

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00782808

Enrollment

Registered

2008-10-31

Start date

2009-03-31

Completion date

2014-04-30

Last updated

2014-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV Infections

Keywords

HIV DNA in Monocytes

Brief summary

Sixty HIV participants will be enrolled and stratified by PBMC HIV DNA levels, either high (greater than or equal to 5000 copies/106 cells) or low (less than 5000 copies/106 cells). Individuals will be enrolled into each group until filled. Screening PBMC HIV DNA levels will be performed at SEARCH in real-time with less than one-week turn around time. All individuals will intend to initiate ARV due to meeting MOPH guidelines for such. The protocol team will work with the primary care physician to facilitate initiation of standard ARV care; however, initiation of ARV is not a requirement of the study and ARV will not be provided by the study.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* HIV-infected individuals meeting MOPH criteria to initiate HAART and planning to initiate HAART within a month of screening. * Consequently, all participants will have plasma CD4 counts at less than 250 cells.

Exclusion criteria

* Head injury with loss of consciousness greater than 1 hour or cognitive sequela * Current/past illicit drug use or positive drug screen for methamphetamines, amphetamines, or cocaine at screening or entry. * Any of the following laboratory abnormalities: * PT/PTT \> the upper limit of normal (ULN) or INR \> 1.1 * Hemoglobin \< 9.0 mg/dL * ALT \> 5x ULN * serum creatinine \> 2x ULN or creatinine clearance \< 30 cc per min by Cockroft-Gault formula * Acute illness within 30 days prior, persistent and active AIDS-defining OI of any organ system or autoimmune disease. * Current or recent fevers or meningeal signs suggestive of CNS opportunistic infection * CNS opportunistic infection, past or present (Patients diagnosed with opportunistic infection after CSF examination will be excluded from further analysis. In such a situation, an additional patient will be enrolled) * History of pre-existing neurologic disease to include stroke, multiple sclerosis or psychiatric illness including schizophrenia, bipolar disorder, anxiety disorder, panic attacks, major depression, or post traumatic stress disorder. Patients with past depression that is controlled and patients with or minor depressive symptoms will be allowed to enroll. * Known learning disability including dyslexia or unable to read or write basic Thai * Positive Hepatitis C serology (Hepatitis C Ab) * Confusion or other signs and symptoms of metabolic encephalopathy or delirium * Other conditions that could explain neurocognitive decline in the opinion of the investigator such as hypothyroidism, vitamin B12 deficiency or neurosyphilis * Pregnancy or metal objects that would preclude MRI

Design outcomes

Primary

Measure	Time frame
To determine the long-term relationship between cognition and HIV DNA in circulating PBMCs and monocytes (CD14+ PBMCs) among patients initiating HAART for the first time	After March 30, 2016

Countries

Thailand

Outcome results