Infection
Conditions
Keywords
postoperative, infection, c-section
Brief summary
This study is designed to demonstrate that women in labor become infected without exhibiting any clinical signs or symptoms of infection.
Detailed description
The infection is a dynamic process probably beginning shortly after the onset of labor. This process continues and is enhanced during active uterine contractions, which result in bacteria from the vagina being drawn up into the uterine cavity. During labor, bacterial colonization of the amniotic fluid, the decidua, and even the fetus can occur, resulting in infection of the mother and the fetus.
Interventions
PROCEDUREBiopsy
1 centimeter x 1/2 centimeter piece cut from uterus
Sponsors
The Woman's Hospital of Texas
Study design
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 48 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients must be afebrile throughout labor. 2. Amniotic fluid must be not purulent; presence of meconium is not an exclusion. 3. Patients undergoing an elective cesarean section. 4. Patients who have labored with intact or ruptured amniotic membranes.
Exclusion criteria
1. Patient with a temperature of ≥ 100.4o F. 2. White blood cell count ≥ 24,000. 3. Suspicion of chorioamnionitis. 4. Suspicion of a urinary tract infection. 5. Presence of diarrhea (defined \> 4 liquid stools in a 24 hour period). 6. Patient currently taking therapeutic antibiotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative infection following rupture of amniotic membranes | Amount of time it takes to obtain culture result |
Countries
United States
Outcome results
None listed