Pain
Conditions
Brief summary
The purpose of this study is to determine the effect of a local anesthetic nerve block on markers of inflammation and pain after a sunburn. This is important because it may provide information regarding the way that nerve blocks help with the treatment of pain and in particular provide preemptive analgesia.
Interventions
PROCEDUREfemoral nerve block
Sponsors
Stanford University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Between 18 and 50 years of age 2. Fluent in English language 3. Provide written informed consent 4. Skin pigmentation type II or III
Exclusion criteria
1. Current use of prescription drugs interfering with study objective 2. Use of over-the-counter analgesic/anti-inflammatory drugs within 48h of study participation 3. Current acute or chronic pain conditions 4. Significant medical conditions including psychiatric, neurological, and dermatological diseases 5. Pregnancy 6. Allergies to study drug(s) 7. Concomitant participation in other study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of the effect of a preemptive peripheral nerve block on the hyperalgesic response to an artificially induced sunburn. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of the effect of a preemptive peripheral nerve block on the release of pro-inflammatory cytokines. | — |
Countries
United States
Outcome results
None listed