Continuous Positive Airway Pressure, Inflammation, Obstructive Sleep Apnea
Conditions
Brief summary
The purpose of this study is to evaluate the effects of CPAP treatment on airway and systemic inflammation in obstructive sleep apnea.
Detailed description
Obstructive sleep apnea (OSA) is characterised by repetitive episodes of upper airway obstruction during sleep. Systemic and airway inflammation has been recently shown to be associated with OSA and is hypothesized to contribute to the clinical manifestation and the complications of OSA patients. Continuous positive airway pressure (CPAP) is a first-line treatment for OSA and improves diurnal and nocturnal symptoms. However, the effectiveness of CPAP in reversing airway inflammation is less compelling in comparison to systemic inflammation. This study will assess NO in exhaled breath, inflammatory biomarkers in induced sputum and blood of OSA patients and other clinical measurements before and after 3 months of CPAP treatment.
Interventions
DEVICECPAP treatment
maintains upper airway patency and minimizes the obstructive events
Sponsors
Kyoto University, Graduate School of Medicine
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects on admission for sleep study under the Respiratory Care and Sleep Control Medicine, Kyoto University Hospital. * Subjects diagnosed with OSA (apnea hypopnea index \>=20/hour) by overnight polysomnography.
Exclusion criteria
* Known history of respiratory diseases that will affect airway inflammatory markers like asthma, chronic obstructive pulmonary disease and bronchiectasis. * Treatments with corticosteroids or other immunosuppressive drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory biomarkers in induced sputum and blood. Cell counts in induced sputum. | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Airway resistance | 3 months |
| PSG measurement(AHI,etc.) | 3 months |
| NO in exhaled breath | 3 months |
| Psychological status | 3 months |
| Sleep quality | 3 months |
| Quality of Life | 3 months |
Countries
Japan
Outcome results
None listed