Metabolic Adaptations to Diabetes in African Americans

Metabolic Adaptations to Diabetes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00780195

Enrollment

Registered

2008-10-27

Start date

1998-07-31

Completion date

2010-12-31

Last updated

2014-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Keywords

hypoglycemia, African Americans

Brief summary

We do not know why diabetic patients cannot protect themselves against low blood sugar. Therefore, in this study, we will perform a comprehensive assessment of the body's response to low blood sugar by measuring changes in blood hormones, blood sugar production, and nerve signals.

Detailed description

Morning and afternoon hypoglycemic episodes of 70, 60, or 50 mg/dl produce increased blunting of subsequent counterregulation dependent upon the depth of preceding hypoglycemia. We wanted to test this hypothesis in healthy African American individuals to determine if there is a difference in their responses to varying depths of hypoglycemia.

Interventions

PROCEDUREglucose clamp

2 hour hyperinsulinemic euglycemic clamp (90 mg/dl)

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy males and females aged 18-40 yrs with no family history of diabetes mellitus. * All prospective volunteers will have routine blood tests to screen for biochemical, hormonal and hematological abnormalities. * Female volunteers will also undergo an HCG urine pregnancy test.

Exclusion criteria

* Prior or current history of poor health * Abnormal results following blood and physical examination * Pregnancy

Design outcomes

Primary

Measure	Time frame
catecholamines	2 hours

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026