Hepatocellular Carcinoma
Conditions
Keywords
Liver cancer, HCC
Brief summary
This is a prospective open label clinical trial in patients with advanced or metastatic liver cancer to assess the clinical and biological activity of RAD001 (Everolimus) in conjunction with Bevazicumab (Avastin). Approximately 36 patients will be enrolled.
Interventions
DRUGEverolimus, Bevacizumab
Everolimus 5 mg tablet per day orally. Bevazicumab 5 mg per kg intravenous every 2 weeks.
Sponsors
Crolll Gmbh
Estimate, GmbH
Janssen Diagnostics, LLC
Gerhard Treiber
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>18 years * Patients with non-resectable locally advanced or metastatic hepatocellular cancer BCLC stage B and C. BCLC stage A can occasionally be included provided that other treatment options are unavailable * Measurable disease: At least one measurable lesion (longest diameter ≥20 mm on conventional CT or MRI scan; ≥ 10 mm on spiral CT) according to RECIST criteria that has not been previously locally treated by irradiation, surgery, ethanol injection, radiofrequency ablation or transarterial chemoembolisation * Confirmation of HCC disease by histology (preceding liver resection or fine needle biopsy within the last 12 months); * Liver Function: Child A and B * Tumor extent: CLIP Score ≤ 3 * ECOG Performance Status 0-2 (=Karnofsky-Index ≥ 60%)
Exclusion criteria
* Patient had received any prior systemic treatment (possible exception: sorafenib for a maximum of 3 months, last dose received at least 28 days before study inclusion) * Patient had a major surgery, local ablative treatments (RFA, PEI), or transarterial chemoembolisation therapy within 4 weeks prior to randomisation * Presence of a secondary malignancy either at the time of screening or in the past 5 years: An exception from this rule can be made in patients that were treated in curative intention within the last 3 years and are without any evidence of recurrence of this malignancy. * History or presence of central nervous system (CNS) disease (i.e., primary brain tumor, malignant seizures, CNS metastases or carcinomatous meningitis) or other mental illness. * Clinically serious infections or uncontrolled infection (including HIV infection), increased risk for acquisition of opportunistic infections * Chronic treatment with systemic steroids or another immunosuppressive agent * Inadequate organ functions, characterised by: cholestasis with elevated levels of bilirubin and/or alkaline phosphatase \> 3x UNL (can be improved by biliary drainage if necessary) and/or elevated transaminases (ALAT/ASAT) ≥ 5 x UNL, hypoalbuminemia \< 2.5 g/dl, renal impairment (serum creatinine \< 1.5 x UNL ), inadequate Hematology: Platelets \< 75.000, ANC \< 1500, hemoglobin \< 9.0 mg/dl, inadequate coagulation status, namely INR \> 2 or Quick \< 50%, aPTT \>50 sec in the absence of any drugs interfering with coagulation such as warfarin, phenprocoumon, NMH or UFH. Fasting serum cholesterol ≤300 mg/dL OR 7.75 mmol/L AND fasting triglycerides ≤ 2.5 x ULN, patients with severe refractory therapy-resistant hyperlipidemia * Women who are pregnant or breast feeding, intended pregnancy, or women unable to conceive and unwilling to practice an effective method of birth control * Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of RAD001 and cannot be controlled by adequate medical treatment (e.g. uncontrolled nausea, vomiting, diarrhoea which might result in malabsorption, any known malabsorption syndrome, bowel obstruction, or inability to swallow the capsules/tablets)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to Progression | 24 and 48 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival | 24 and 48 weeks |
Countries
Germany
Outcome results
None listed