Ventricular Remodeling In Patients With Aortic Stenosis Assessed Echocardiography

Patterns Of Left Ventricular Remodeling In Patients With Aortic Stenosis Assessed By Two-Dimensional And Three-Dimensional Echocardiography

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00774657

Enrollment

Registered

2008-10-17

Start date

2008-09-30

Completion date

2012-02-29

Last updated

2012-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Stenosis

Keywords

Aortic Stenosis, Valvular heart disease, Heart disease, Cardiovascular disease, Two dimensional echocardiography, Three dimensional echocardiography

Brief summary

This preliminary study will compare the effectiveness of two-dimensional and three-dimensional echocardiographic measurements of wall thickness and left ventricular mass in patients with Aortic Stenosis

Detailed description

This study will evaluate left ventricular patterns of remodeling and hypertrophy in patients with aortic stenosis, and compare two-dimensional echocardiography measurements (wall thickness) with three-dimensional echocardiography data(left ventricular mass). Along with a second objective to assess Doppler diastolic filling indices associated with the various patterns of left ventricular remodeling. Previous studies(see reference list) were primarily derived from two-dimensional echo data set(based on wall thickness). Various patterns of left ventricular remodeling have been described in response to increased pressure overload. Three-dimensional echocardiography is a relatively new technique that is being increasingly used in the Echocardiography Lab in selected patients. This technique holds promise of being more accurate for volume-related measurements than the standard 2-dimensional echocardiography techniques.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Subjects more than 18 yrs of age through 90 yrs of age * Both male and female * Patients with moderate or severe isolated Aortic Stenosis * Patients who have been referred for both two-dimensional and three- dimensional echocardiographies.

Exclusion criteria

* Poor acoustic windows * h/o CAD and wall motion abnormality

Design outcomes

Primary

Measure	Time frame
Evaluate 2-dimensional and 3-dimensional echocardiography for LV patterns of remodeling and hypertrophy	1 hour

Secondary

Measure	Time frame
Assess doppler diastolic filling indices for patterns of LV remodeling	1 hour

Countries

United States

Outcome results