Acute Pain and Inflammation After Surgery

Acute Pain and Role of Ketolorac in Inflammatory Mediators After Knee Arthroscopy Evaluated by Microdialysis

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00774540

Acronym

Knemikro01

Enrollment

Registered

2008-10-17

Start date

2008-08-31

Completion date

2014-12-31

Last updated

2015-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Injuries

Keywords

Acute pain, Inflammatory pain, Inflammatory mediators, Pain relief, Microdialysis

Brief summary

The purpose of this study is 1. to observe acute pain after surgery and measure the natural course of inflammatory mediators 2. study pain relieving effects and local anti-inflammatory effects of systemically administered ketorolac

Detailed description

Randomizized controlled trial

Interventions

DRUG1 Ketorolac intraarticular

Ketorolac intraarticular 5 mg

DRUGPlacebo

Saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Day case surgical patients above 18 years old * Non pregnant

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
Pain relief local anti-flammatory effects	2 h

Secondary

Measure	Time frame
Rescue analgesic consumption	2 h

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026