Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00774488

Enrollment

Registered

2008-10-17

Start date

2006-01-31

Completion date

2007-07-31

Last updated

2008-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin Sensitivity, Metabolic Syndrome, Obesity

Keywords

Euglycemic-hyperinsulinemic clamp, fat biopsies, microarray analysis, quantitative real time PCR, overnutrition, low grade-inflammation

Brief summary

This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.

Interventions

OTHERGlucose dependent insulinotropic polypeptide (GIP)

GIP-Infusions for 4 h in a postprandial concentration

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI \> 28 * Healthy subjects * Normal glucose tolerance

Exclusion criteria

* Diabetes,IFG, IGT * Chronical-inflammatory diseases * Hb \< 12g/dl * Elevation in liver enzymes or creatinin concentrations * Great weight changes within last 12 months * Any cancer diagnosis in last 10 years

Design outcomes

Primary

Measure	Time frame
Changes in gene expression of subcutaneous adipose tissue with microarray analysis	3 years

Secondary

Measure	Time frame
Analysis of inflammatory marker (blood levels and gene expression), Activity of 11beta HSD and 11-beta HSD mRNA in adipose tissue, etc.	3 years

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 17, 2026