Liver Function
Conditions
Keywords
all adult patients (>18 years) planned to undergo a major liver resection
Brief summary
We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.
Interventions
DRUGdextrose 10% (D10W ®) infusion
Started at 8pm the day before surgery until the procedure begins
Started as the procedure begins, decreased at the end of the procedure and continued until 16 hours postoperatively
DIETARY_SUPPLEMENThigh calorie diet 35 kcal/kg
High Calorie meals start the day before the surgery and are given 5 hours apart. The last meal is given at 7 pm the day before surgery
Intravenous normal saline (NS 0.9) started just before induction, and titrated to hemodynamic parameters and urine output
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 18 years or older * planned to undergo a major liver resection at McGill University Health Center (MUHC)
Exclusion criteria
* patients known with chronic viral liver disease * uncontrolled or type one diabetes mellitus (DM) * patients on oral beta-blocker agents * patients with unresectable disease determined intra-operatively * patients unable to give consent for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative liver function test | Postoperative |
Secondary
| Measure | Time frame |
|---|---|
| Liver and muscle glycogen, TG, and protein content at beginning and end of the procedure. | Begining + end of the procedure |
| Incidence of complications | Postoperative |
Countries
Canada
Outcome results
None listed