Identification of Novel Targets for Regulation of Adipose Tissue Mass

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00773565

Enrollment

Registered

2008-10-16

Start date

2008-10-31

Completion date

2011-08-31

Last updated

2012-08-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

patients with obesity (BMI > 30 kg/m2)

Brief summary

The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.

Interventions

DIETARY_SUPPLEMENTOptifast

Formula diet for twelve weeks combined with physical activity and behavioral therapy

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Participants of the OPTIFAST52 program * BMI \> 30 kg/m2

Exclusion criteria

* Rejection of informed consent by the participant

Design outcomes

Primary

Measure	Time frame
number of adipocytes and preadipocytes under weight loss	three years

Secondary

Measure	Time frame
metabolic function of adipocytes and preadipocytes under weight loss	three years

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026