Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS)

Effect of Treatment With Stress-Doses Glucocorticoid on Mortality in Patients With ARDS and Relative Adrenal Insufficiency

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00773058

Enrollment

100

Registered

2008-10-16

Start date

2008-12-31

Completion date

Unknown

Last updated

2009-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Distress Syndrome, Adrenal Insufficiency

Keywords

acute respiratory distress syndrome, glucocorticoid, adrenal insufficiency

Brief summary

The purpose of this study is to see if stress doses of hydrocortisone improve early outcome in patients who are in early stage of ARDS and with relative adrenal insufficiency.

Interventions

DRUGhydrocortisone

hydrocortisone 100mg q8h

DRUGplacebo

normal saline 100ml q8h

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* within the first 3 days of onset of clinically definite ARDS confirmed by AECC criteria in 1994 * 18 to 85 year old

Exclusion criteria

* pregnancy or lactation * tumor or other immunologic disease * immunosuppressive drug used * bone marrow or lung transplantation * primary or secondary disease of adrenal gland * hormone used within 3 months * refusing conventional therapy * be in other clinical tests within 30 days

Design outcomes

Primary

Measure	Time frame
Evidence of clinically definite ARDS confirmed by AECC criteria in 1994	within the first 3 days after surgery onset of ARDS

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026