Local Infiltration Analgesia in Major Spine Surgery With Ropivacaine Versus Placebo

Lokal Infiltrations Analgesi Med Ropivakain 0,5 % Versus Placebo Ved Rygkirurgi for Spinalstenose: et Prospektivt Randomiseret, Dobbeltblindet, Placebo-kontrolleret Studie

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00771459

Enrollment

Registered

2008-10-13

Start date

2008-10-31

Completion date

2009-08-31

Last updated

2011-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative

Keywords

Local infiltration analgesia, postoperative pain, ropivacaine

Brief summary

The purpose of this study is to examine whether local infiltration analgesia (LIA) with Ropivacaine and adrenaline is effective in the treatment of postoperative pain after major spine surgery.

Interventions

DRUGRopivacaine 0.5 %

Local infiltration analgesia

DRUGIsotonic NaCl

Local infiltration analgesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* patients eligible for major spine surgery * must speak and understand Danish * must be able to give oral and written consent

Exclusion criteria

* alcohol or medicine abuse * treatment with opioids \> 100 mg daily * allergy to local anesthetics * severe obesity

Design outcomes

Primary

Measure	Time frame
Postoperative Pain	0-48 h postoperatively

Secondary

Measure	Time frame
Analgesia consumption	0-48 h postoperatively

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026