Hypothyroidism
Conditions
Keywords
insulin sensitivity, Substrate metabolism, Fatty liver, intramyocellular lipid, intracellular signaling
Brief summary
The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism
Interventions
DRUGLevothyroxin
Dosage regulation will follow the local recommendations of treatment
Sponsors
MR Research Center, Skejby Sygehus, Brendstrupgaardsvej 100, 8200 Aarhus N
University of Aarhus
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* written informed consent * must be of legal age and competent * Age \> 18 years * presently diagnosed with hypothyroidism
Exclusion criteria
* alcohol consumption \>21 units per week * Malignant disease * pregnancy * magnetic implants or material in the body * BMI \> 30 * Heart disease (NYHA \>2) * Uncontrolled hypertension * Manifest diabetes mellitus * Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intracellular signaling in the basal state and during insulin stimulation | before and after treatment |
| intraabdominal lipid content | before and after treatment |
| insulin sensitivity | before and after treatment |
| substrate metabolism | before and after treatment |
| intracellular lipid content in liver and muscle | before and after 3 months treatment with growth hormone |
Countries
Denmark
Outcome results
None listed