Crohn's Disease
Conditions
Brief summary
We propose to study the intestinal secretion of ASCA by evaluating them in biopsy culture supernatants from a cohort of patients suffering from CD (n=80) and a cohort of control patients (UC (n=40) and patients without IBD (n=40 )).
Detailed description
Its diagnosis is based upon clinical, endoscopic and histological parameters but recent studies have shown that seric evaluation of immunological markers (anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic auti-antibodies (ANCA)) could be useful. Crohn's disease (CD) is an inflammatory bowel disease (IBD) of the young people. Antibodies anti-chitobisoside carbohydrate (ACCA), anti-laminaribioside carbohydrate (ALCA) and anti-mannobioside carbohydrate (AMCA) have been described as new serological markers of CD.
Interventions
OTHERBlood sampling and biopsy
Biopsy and blood : Research for various antibodies
OTHERBiopsy and blood sampling
Biopsy and blood : research for various antibodies
Sponsors
Assistance Publique Hopitaux De Marseille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients reached by disease of crohn * patients reached by hemorrhagic first side-colitis
Exclusion criteria
* Forms ileales or ano-périneales pure of disease of crohn * indefinite colitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare the performances of the dosage of the ASCA in floating it of culture of intestinal biopsies in that of their dosage in the serum | 24 months |
Secondary
| Measure | Time frame |
|---|---|
| Determine if the patients reached by disease of crohn not presenting ASCA in their serum represent one under group of disease of crohn | 24 months |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORSophie Desplat-Jego, MD
Assistance Publique des Hopitaux de Marseille
Outcome results
None listed