Structural and Functional Left Ventricular Remodelling in Patients With Obstructive Sleep Apnea

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00768807

Enrollment

450

Registered

2008-10-08

Start date

2009-10-31

Completion date

2010-09-30

Last updated

2012-05-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Brief summary

The purpose of this study is to determine whether patients with obstructive sleep apnea have any changes in left ventricular function and structure after 06 months of continuous positive airway pressure treatment.

Detailed description

Several studies have been suggesting that Obstructive Sleep Apnea contributes to deterioration of left ventricular diastolic function. It may be associated to increased risk of cardiovascular events. We hypothesized that morphological and functional left ventricular changes might be reverted after treatment with Continuous positive airway pressure.

Interventions

DEVICECPAP (continuous positive airway pressure)

Patients treated by CPAP for 06 months

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

35 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Apnea-hypopnea index higher than 5 events per hour

Exclusion criteria

* Body mass index higher than 40 kg/m2

Design outcomes

Primary

Measure	Time frame
Improvement of left ventricular diastolic echo variable	06 months

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 2, 2026