Diabetes and Metabolic Postprandial Responses

Comparison of Postprandial Metabolic Responses Between Type 2 Diabetic and Healthy Overweight Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00767208

Enrollment

Registered

2008-10-07

Start date

2005-01-31

Completion date

2008-05-31

Last updated

2009-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight, Type 2 Diabetes

Keywords

type 2 diabetic subjects

Brief summary

The aim of this trial was to compare postprandial metabolic response to glucose load in healthy overweight and type 2 diabetic subjects, by using glycemia, insulinemia, lipid profile, nutrient oxidation follow-up. Stable isotopes of glucose were used to assess postprandial total,exogenous and endogenous glucose kinetics.

Interventions

OTHERoral glucose load

oral ingestion of 13C labeled glucose

Study design

Intervention model

PARALLEL

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

30 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Overweight or obese volunteers * Healthy for one group nd type 2 diabetic for the second group * Age between 30 and 65 years old * Total cholesterol \< or = 7 mmol/l and triglycerides \< or = 4 mmol/l * For diabetic group: treated by metformin and/or sulfonylurea and/or thiazolidinedione and HbA1c \< 6% * Stable weight over last 3 months * Informed consent

Exclusion criteria

* No compliant subjects * Participation in an other trial 2 months before starting this one * Ward of court or under guardianship (sheltered adults) * Person deprived of freedom by judicial or administrative decision * Type 1 diabetes and type 2 diabetes treated bu insulin or acarbose * Existence of a previously diagnosed pathology (other than type 2 diabetes) * Previous gastro-intestinal pathology * Treated by corticoids, anorexigens, weight loss medicines * Alcoholism or severe tobacco consumption

Design outcomes

Primary

Measure	Time frame
Apparition of exogenous glucose in plasma in the postprandial phase and its effect on carbohydrate and lipid metabolism	6 hours postprandially

Secondary

Measure	Time frame
Postprandial concentrations of glucose, non esterified fatty acids, insulin and triglycerides	6 hours postprandially
Carbohydrate and lipid oxidation	6 hours postprandially

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026