Insulin Resistance, Obesity
Conditions
Keywords
Obesity, Insulin resistance, Gastric tube, Ghrelin
Brief summary
The purpose of this study is to determine whether gastric division (via Roux-en-Y gastric bypass) with resultant fundic isolation will alter the pattern(s) of Ghrelin secretion in the early post-operative period following feeding in morbidly obese subjects.
Interventions
OTHERLiquid diet for 3 days
The control group were given a 3 -day liquid diet similar to the RYGB post-op diet
Sponsors
Vanderbilt University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Serum creatinine and liver function tests \< upper limits of normal * Stable body weights for the past three months * Women will have a negative pregnancy test * patients who are already scheduled for RYGB with gastrostomy tube placement
Exclusion criteria
* Significant hepatic enzyme elevations (more than 100% of upper limits of normal) * Serum creatinine \> 1.5 mg/dl * history of ketoacidosis or current metabolic acidosis * current use of oral anticoagulants * Positive pregnancy test (beta-human chorionic gonadotrophin) for females * intercurrent infections * patients with prior gastric operations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ghrelin | pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op |
Secondary
| Measure | Time frame |
|---|---|
| HOMA | pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op |
| metabolic hormones | pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op |
Countries
United States
Outcome results
None listed