Dental Plaque
Conditions
Brief summary
Training and calibration of dental examiners
Interventions
DRUGFluoride
Brush half mouth twice daily for four days
DRUGTriclosan
Brush half mouth daily for four days
DRUGChlorhexidine gluconate
Mouth rinsing with 15 ml for 30 seconds twice a day for four days
Sponsors
Colgate Palmolive
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female volunteers 18-65 years of age * Good general health * Must sign informed consent form * Minimum of 20 natural uncrowned teeth (excluding third molars) must be present. * No history of allergy to personal care consumer products, or their ingredients, relevant to any ingredient in the test products as determined by the dental/medical professional monitoring the study.
Exclusion criteria
1. Subjects unable or unwilling to sign the informed consent form. 2. Medical condition which requires pre-medication prior to dental visits/procedures 3. Moderate or advanced periodontal disease or heavy dental tartar (calculus). 4. 2 or more decayed untreated dental sites at screening. 5. Other disease of the hard or soft oral tissues. 6. Impaired salivary function (e.g. Sjogren's syndrome or head and neck irradiation). 7. Use of medications that can affect salivary flow (e.g. anticholinergics, adrenergics, antihistamines, vasoconstrictors or decongestants). 8. Use of antibiotics or antimicrobial drugs within 30 days prior to study visit #1. 9. Pregnant or nursing women. 10. Participation in any other clinical study within 1 week prior to enrollment into this study. 11. Allergy to chlorhexidine 12. Use of tobacco products 13. Subjects who must receive dental treatment during the study dates. 14. Current use of Antibiotics for any purpose. 15. Presence of an orthodontic appliance. 16. History of allergy to common dentifrice ingredients. 17. Immune compromised individuals (HIV, AIDS, immuno suppressive drug therapy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dental plaque | 6 weeks |
Countries
United States
Outcome results
None listed