Acute on Chronic Hepatic Failure, Cirrhosis, Encephalopathy, Hepatorenal Syndrome
Conditions
Keywords
Albumin dialysis, Artificial liver support, Acute on chronic liver failure
Brief summary
The aim of this study is to determine whether a simplified device of albumin dialysis also has beneficial effects.
Detailed description
Albumin dialysis has beneficial effects in patients with acute on chronic liver failure. However, current devices are complex and costly. The aim of this study is to determine whether a simplified device of albumin dialysis also has beneficial effects.
Interventions
DEVICESingle pass albumin dialysis
6 hours sessions of albumin dialysis.
Sponsors
Laboratoire français de Fractionnement et de Biotechnologies
Institut National de la Santé Et de la Recherche Médicale, France
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Minimum age of 18 years * Written consent after information of the patient or, in case of inability, by a parent or a close if he is present. * Patient having a cirrhosis researched by previous exams (liver biopsy) or, in the absence of previous diagnosis, diagnosed in view of the results of clinical, biological and morphological data, whatever the origin of the cirrhosis (virus of hepatitis B, virus of hepatitis C, extreme consumption of alcohol or other reasons)
Exclusion criteria
* Participation to an other study in the 4 weeks before * Active digestive bleeding, unchecked by the pharmacological treatments and the endoscopic techniques.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects on clinical and biochemical variables | 3 months follow-up |
Secondary
| Measure | Time frame |
|---|---|
| Safety | 3 months |
Countries
France
Outcome results
None listed