Norepinephrine Weaning in Septic Patients

Continuous Administration of Norepinephrine Assisted by Fuzzy Logic Assisted Control in Septic Shock Patients

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00763906

Acronym

CATECHOFLOU

Enrollment

Registered

2008-10-01

Start date

2004-11-30

Completion date

2007-01-31

Last updated

2008-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Keywords

septic shock, fuzzy logic, norepinephrine weaning

Brief summary

The weaning rate of vasopressors drugs is usually chosen empirically by the clinician in critically patients. The investigators applied fuzzy logic principles to modify intravenous norepinephrine infusion rates during norepinephrine infusion in septic patients in order to reduce the duration of shock. The investigators goal was to reduce the duration of poorly controlled hemodynamic status.

Interventions

DEVICEnorepinephrine infused at the clinician's discretion

DEVICEnorepinephrine infused under computerized fuzzy logic control

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Septic shock

Exclusion criteria

* Less than 18 years * Pregnancy * Weight above 135 kg * Requirement for continuous epinephrine infusion * Severe head injury, stroke, a comatose state following cardiac arrest

Design outcomes

Primary

Measure	Time frame
Time to shock resolution defined as cessation of vasopressor support	—

Secondary

Measure	Time frame
28 days survival, total amount of norepinephrine infused, duration of mechanical ventilation, and length of stay in the ICU	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 4, 2026