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Transcranial Magnetic Stimulation (TMS) for Treatment of Auditory Hallucinations

A Pilot Study Using Transcranial Magnetic Stimulation (TMS) to Investigate the Role of the Temporal Cortex in Schizophrenic Patients With Auditory Hallucinations

Status
Completed
Phases
Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00763841
Enrollment
18
Registered
2008-10-01
Start date
1999-09-30
Completion date
2008-09-30
Last updated
2010-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Auditory Hallucinations

Keywords

Auditory hallucinations

Brief summary

Transcranial magnetic stimulation (TMS) involves the use of magnetic fields to non-invasively stimulate the brain. Studies overseas have suggested this may be an effective and safe treatment for auditory hallucinations in patients with schizophrenia. This is a sham-controlled, double-blind trial of TMS stimulation for the treatment of auditory hallucinations in patients with schizophrenia.

Interventions

DEVICETranscranial magnetic stimulation

Stimulation will be given daily at a particular site for three days a week

DEVICESham

Sponsors

NSW Schizophrenia Fellowship
CollaboratorUNKNOWN
Rebecca Cooper Medical Research Foundation
CollaboratorUNKNOWN
The University of New South Wales
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Over 18, with DSM-IV diagnosis of Schizophrenia and auditory hallucinations of clear external origins, refractory to pharmacotherapy and occurring at least 5 times per day.

Exclusion criteria

* Subjects with contraindications to TMS (e.g. epilepsy, pacemaker) or those with an unacceptably high risk (e.g. suicide risk) will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
Daily Voices Ratings (Mental Health Research Institute, Victoria)Daily

Countries

Australia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026