Antidepressant Drug Exposure and Risk of Suicide Attempt Resulting in Medical Intervention in US Adults

A Propensity-Matched Retrospective Cohort Study of Antidepressant Drug Exposure and Risk of Suicide Attempt in Adults From a Large U.S. Managed Care Population

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00763724

Enrollment

254432

Registered

2008-10-01

Start date

2008-06-30

Completion date

2009-11-30

Last updated

2010-03-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Suicide

Brief summary

The primary objective of the study is to estimate the incidence of suicide attempts resulting in a medical encounter or hospitalization in seven propensity matched cohorts of subjects: patients treated with duloxetine for depression, patients treated with one of three other antidepressants or antidepressant classes (venlafaxine, SSRIs, or TCAs) for depression, patients treated with multiple antidepressants for depression (either concurrently or consecutively), depressed patients with no pharmacologic treatment, and a non-depressed general population sample.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 years or older at index date * Have at least 6 months of continuous enrollment data prior to index date. * Have complete medical, facility, and pharmacy records (the latter of which will include complete quantity and days supplied information).

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame
Incidence of suicide attempt resulting in medical encounter or hospitalization.	Endpoint

Secondary

Measure	Time frame
Relative risk of suicide attempt resulting in medical encounters or hospitalization	Endpoint

Outcome results