Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis in Patients With HIV?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00763295

Enrollment

Registered

2008-09-30

Start date

2008-05-31

Completion date

2010-01-31

Last updated

2012-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV Infections, Latent Tuberculosis

Keywords

latent tuberculosis, HIV, IFN-γ based assay

Brief summary

HIV infection highly increases the risk of progression of latent tuberculosis (TB) to active disease that therapy is recommended for all PPD-positive, HIV-infected patients, regardless of age. Sensitivity of the PPD testing is, however, dependent on a normal T cell function. Therefore, an accurate and reliable method for detection of latent tuberculosis in patients with HIV is urgently needed. This prospective study will examine the utility of interferon-gamma (IFN-γ) based assay, T-SPOT.TB,for detection of TB in HIV-infected individuals.

Interventions

OTHERT-Spot.TB test

diagnostic test

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* adult individuals with confirmed HIV infection

Exclusion criteria

* Patients who are on INH treatment * Patients who have a positive PPD test within 1 year of study enrollment * Individuals with blistering or ulcerating skin disorder * Pregnant women * Patients who were given blood transfusion within 6 weeks prior to enrollment

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026