Stroke
Conditions
Keywords
inflammation, coagulation, neuroprotection, drugs, clinical neurology, pharmacology, biological factors
Brief summary
In a previous suty, we have demonstrated that prior transient ischemic attack, treatment lipid-lowering drug or physical activity are associated to a better outcome of stroke. The aim of the study is to understand the mechanisms of this preventive neuroprotection by establishing link between biomarkers and preventive and neuroprotective measures.To answer to the question, we conduct a cohort study of stroke patients.
Detailed description
In the cohort, the severity of stroke (NIHSS) will be correlated with : * clinical factors, * pharmacological factors, * biological factors (inflammatory markers, hemostasis...)
Interventions
None listed
Sponsors
University Hospital, Lille
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ischemic or hemorrhage stroke * hemispheric stroke * stroke dating from less 48h
Exclusion criteria
* non hemispheric stroke * malformative intracranial hemorrhage * traumatic intracranial hemorrhage * subarachnoidal hemorrhage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| severity of stroke measured by NIH severity score | inclusion, day7, month3, year3 |
Secondary
| Measure | Time frame |
|---|---|
| clinical, pharmacological and biological (metabolic, inflammation, hemostasis...) cognitive status | inclusion and year3 |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORregis BORDET, MD,PhD
University Hospital, Lille
Outcome results
None listed