Juvenile Idiopathic Arthritis
Conditions
Keywords
Juvenile Idiopathic Arthritis, JIA, Arthritis, Osteoporosis, Osteoporosis in Children
Brief summary
The purpose of this study is to compare healthy children to children who have a chronic illness called Juvenile Idiopathic Arthritis (JIA). JIA is a childhood disease that causes swollen joints that are often stiff and painful. JIA affects about 1 in 1,000 children age 16 and younger.
Detailed description
Children with chronic illnesses are at risk for bone fragility due to inflammation, glucocorticoid therapy, physical activity limitation, malnutrition, and pubertal delay. The impact of low bone mass during childhood may be immediate, resulting in childhood fractures, or delayed, due to suboptimal peak bone mass attainment.
Interventions
None listed
Sponsors
Children's Hospital of Philadelphia
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
5 Years to 21 Years
Healthy volunteers
Yes
Inclusion criteria
* for JIA patients: subjects age 5-21 Drawn from Dr. Burnham's prospective cohort study of bone health in 101 children with arthritis. * for Control patients: subjects age 5-21 Controls will be a 50% male/female
Exclusion criteria
* for JIA patients: Subjects with JIA will be excluded if they have conditions or drug exposure unrelated to JIA and known to impact growth or bone health. * for Control patients: Chronic disease or syndrome known to affect growth or bone health, prematurity (\<37 weeks gestation), or use of any medication known to affect growth.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lumbar spine volumetric Bone Mineral Density (vBMD) and vertebral size will vary according to sex, age and pubertal stage. | same day |
Secondary
| Measure | Time frame |
|---|---|
| Children with JIA will have lower vertebral stiffness and strength, compared with controls. | same day |
Countries
United States
Outcome results
None listed