Studies on the Expression and Functions of RLIP76 in Blood Samples of Healthy Human Subjects

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00762801

Enrollment

Registered

2008-09-30

Start date

2008-09-30

Completion date

2011-09-30

Last updated

2016-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

RLIP76, Cancer, apoptosis

Brief summary

RLIP76 (Ral binding protein1) is a 76 kDa splice variant protein encoded by the human gene (RALBP1, 18p11.22). It is a multifunctional modular protein found ubiquitously from Drosophila to humans, in cells ranging from red blood cells to endothelial cells of the brain. Its expression more predominant in breast, heart, liver and less so in colon and brain parenchyma.

Detailed description

RLIP76 is shown to be over expressed in a variety of cancer cells. However, no study has yet been done on its expression on normal cells. The studies proposed in this project will study the expression of RLIP76 in blood cells of healthy human subjects in the population of North Texas region.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy as defined by lack of serious health conditions or diseases

Exclusion criteria

* Children, pregnant women, prisoners, persons with any medical condition that precludes phlebotomy and persons unwilling or unable to provide consent will be excluded.

Design outcomes

Primary

Measure	Time frame
Expression of RLIP76 in red blood cells and white blood cells of 100 healthy human subjects.	3 years

Secondary

Measure	Time frame
To investigate the RLIP76 mediated transport of glutathione conjugates and chemotherapeutic drugs.	3 years

Countries

United States

Outcome results