Gingival Diseases
Conditions
Brief summary
The efficacy of two dentifrices in controlling gingivitis and plaque in adults with implants
Interventions
DRUGFluoride
Brush twice daily
Brush twice daily
Sponsors
Colgate Palmolive
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 76 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and females in good oral and general health aged 18 to 76 years. * A willingness to read, understand, and sign the Informed Consent Form after the nature of the study has been fully explained to them. Subject should demonstrate willingness to comply with all study procedures and availability for duration of study. * Subjects will use the provided test articles and discontinue the use of other dentifrices and mouthrinses for the duration of the study. * A minimum of 20 natural teeth with facial and lingual scorable surfaces. Teeth that are grossly carious, fully crowned or extensively restored on facial and/or lingual surfaces, orthodontically banded, abutments, or third molars will not be included in the tooth count. * Adequate oral hygiene and no signs of oral neglect. * Subjects will have at least one dental implant and a contralateral natural tooth. * At the first visit subjects will be examined by a dentist for periodontal health. * Selected subjects will have periodontal pockets less than 6mm. * Subjects with gingival index equal to or greater than 1.0 and plaque index equal to or greater than or 1. 5 on the implant tooth will be enrolled. Gingival and plaque indices will be measured during the first visit for the implant. Similarly, these clinical indices (Gingival and plaque index) will be determined for the contralateral natural tooth. (The adjacent teeth will serve as a backup for the studies if control tooth is lost during study). * Subjects who are habitual users of Colgate Total or other oral hygiene formulations with antimicrobial agents will complete a washout phase of 30 days with a commercial fluoride dentifrice prior to enrollment in the study. This washout dentifrice will be identified and obtained by the clinical investigator from an appropriate local source.
Exclusion criteria
* History of significant adverse effects following use of oral hygiene products such as toothpastes and mouthrinses. Allergy to personal care/consumer products or their ingredients. * Regular use of mouthwash with antimicrobial agents within the past month. * History of diabetes or hepatic or renal disease, or other serious medical conditions or transmittable diseases, e.g. heart disease or AIDS. * History of hepatitis, rheumatic fever, pacemaker, or prosthetic heart valves, heart murmur, mitral valve prolapse or other conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures. * Subjects presenting significant medical conditions or need for long term drug therapy. * Subjects on antibiotic, anti inflammatory or anticoagulant therapy during the month preceding the baseline exam. * Significant oral soft tissue pathology, systemically related gingival enlargement, severe gingivitis (based on a visual examinations) that would interfere with the study. * History of active severe periodontal disease with bleeding gums and loose teeth. * Widespread caries or chronic neglect. Subjects presenting with gross dental caries, severe generalized cervical abrasion and/or enamel abrasion, and large fractured or temporary restorations (based on visual examinations). * Fixed or removable orthodontic appliance or removable partial dentures. * Participation in any clinical study including dental plaque/gingivitis clinical trial involving oral care products, within the last 30 days. History of dental prophylaxis or treatments in the month preceding the start of study. * Self reported pregnancy or lactation. * History or current use of objects to pierce the lips or tongue. * Subjects known to be an alcoholic, or a recovering alcoholic. * History or current use of recreational drugs or narcotics. * Determine smoking status of subjects and exclude current smokers. * Determine reason for placing implants in subject to exclude subjects whose implants were placed for trauma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mombelli Plaque Index (mPI) for Natural Teeth | 3 months | Modified Plaque Index (mPI)is a Dental plaque scale as follows 0 = No plaque, 1 = Separate flecks of plaque at the cervical margin;2 = Plaque can be seen by naked eye.3 = Abundance of soft matter. The lower the number the less plaque is present on the tooth. |
| Mombelli Plaque Index (mPI) for Dental Implants | 3 months | Modified Plaque Index (mPI) is a dental plaque scale as follows 0 = No plaque, 1 = Separate flecks of plaque at the cervical margin;2 = Plaque can be seen by naked eye.3 = Abundance of soft matter. The lower the number the less plaque is present on the tooth. |
| Löe-Silness Gingival Index Score (GI) - Natural Teeth | 3 months | Gingivitis score(GI) is defined: 0 = Absence of inflammation,1 = Mild inflammation-slight change in color and little change in texture,2 = Moderate inflammation-moderate glazing,redness,edema & hypertrophy,3 = Severe inflammation-marked redness and hypertrophy tendency for spontaneous bleeding. Each tooth is scored on 6 surfaces:mesio-facial;2)mid-facial;3)disto-facial;4)mesio-lingual;5)mid-lingualand 6)disto-lingual. A whole mouth score = adding all the GI scores & dividing by the total of number of sites scored. 3rd molars and teeth with restorations or crowns will be excluded. |
| Löe-Silness Gingival Index Score (GI)- Dental Implants | 3 months | Gingivitis Score (GI) is defined: 0 = Absence of inflammation,1=Mild inflammation-slight change in color and little change in texture,2 = Moderate inflammation-moderate glazing,redness,edema & hypertrophy,3 = Severe inflammation-marked redness and hypertrophy tendency for spontaneous bleeding. Each tooth is scored on 6 surfaces:mesio-facial;2)mid-facial;3)disto-facial;4)mesio-lingual;5)mid-lingualand 6)disto-lingual. A whole mouth score=adding all the GI scores & dividing by the total of number of sites scored. 3rd molars and teeth with restorations or crowns will be excluded. |
| Gingival Bleeding on Probing (BOP) Using Sulcus Bleeding Index for Teeth | 3 months | Sulcus bleeding index for teeth is explained here. Gums around teeth are scored:0 = gingiva of normal texture & color, no bleeding;1 = gingiva normal, bleeds on probing;2 = bleeding on probing,change in color, no oedema; 3 = bleeding on probing,change in color, slight oedema;4 = bleeding on probing, change in color, obvious oedema;5=bleeding on probing, spontaneous bleeding, change in color, marked oedema. |
| Gingival Bleeding on Probing (BOP) Using the Modified Sulcus Bleeding Index for Implants | 3 months | Gingival bleeding on probing (BOP) using the modified sulcus bleeding index for implants. Scale equals 0 = No bleeding when periodontal probe is passed along the gingival margin;1 = Isolated bleeding spots visible;2 = Blood forms a confluent red line on the gingival margin;3 = Heavy or profuse bleeding. |
| A.Actinomycetemcomitans (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are Least means square (LSM)determined by baseline adjusted means including Standard Error of means (SEM). |
| A.Actinomycetemcomitans (DNA Probe Analysis)- Natural Teeth | 6 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data point is Least means square (LSM) determined by baseline adjusted means including Standard Error of Means (SEM). |
| A.Actinomycetemcomitans (DNA Probe Analysis)- Dental Implant | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implant. Data point is Least means square (LSM) determined by baseline adjusted means including Standard Error of Means (SEM). |
| C.Rectus (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM). |
| C.Rectus (DNA Probe Analysis) - Dental Implant | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM). |
| Capnocytophaga sp. (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM). |
| Capnocytophaga sp. (DNA Probe Analysis) - Dental Implant | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM). |
| E.Corrodens (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM)determined by baseline adjusted means including standard error of means (SEM). |
| E.Corrodens (DNA Probe Analysis) - Dental Implant | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM)determined by baseline adjusted means including standard error of means (SEM). |
| E.Saburreum (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| E.Saburreum (DNA Probe Analysis)- Natural Teeth | 6 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM)detemined by using baseline adjusted means including standard error of means (SEM). |
| E.Saburreum (DNA Probe Analysis) - Dental Implant | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| F.Nucleatum (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM)determined by using baseline adjusted means including standard error of means (SEM). |
| F.Nucleatum (DNA Probe Analysis) - Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM)determined by using baseline adjusted means including standard error of means (SEM). |
| Neissera sp. (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| Neissera sp. (DNA Probe Analysis) Natural Teeth | 6 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points least means square (LSM) determined by baseline adjusted means including standard error of means (SEM). |
| Neissera sp. (DNA Probe Analysis) - Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| P.Gingivalis (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error of means (SEM) |
| P.Gingivalis (DNA Probe Analysis) - Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error of means (SEM) |
| P.Intermedia (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| P.Intermedia (DNA Probe Analysis) - Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| T.Forsythia (DNA Probe Analysis)- Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for both natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| P.Melaninogenica (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| P.Melaninogenica (DNA Probe Analysis) - Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| Solobacterium (S.Moorei)(DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| Solobacterium (S.Moorei)(DNA Probe Analysis) - Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| Streptococci (DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means )SEM). |
| Streptococci (DNA Probe Analysis) - Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means )SEM). |
| T.Forsythia (DNA Probe Analysis)-Natural Teeth | 6 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| T.Forsythia (DNA Probe Analysis)- Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for both Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM). |
| Veillonella sp.(DNA Probe Analysis) - Natural Teeth | 3 months | 14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error (SEM) |
| Veillonella sp.(DNA Probe Analysis) - Dental Implants | 3 months | 14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error (SEM) |
Countries
Israel, United States
Participant flow
Recruitment details
subjects were recruited by the PI at the clinical site
Pre-assignment details
subjects were screened for medical and oral health criteria and given the assigned study treatment to brush with for the next 6 months. Enrolled subjects all had 1 dental implant and 1 natural tooth identified and used for clinical data information.
Participants by arm
| Arm | Count |
|---|---|
| A - Fluoride Control Fluoride toothpaste (Ultrabrite)group contained both 1 natural tooth site and 1 dental implant site for clinical assessment. | 55 |
| B - Postive Control fluoride/triclosan/copolymer toothpaste group contained both 1 natural tooth site and 1 dental implant site for clinical assessment. | 50 |
| Total | 105 |
Baseline characteristics
| Characteristic | Total | A - Fluoride Control | B - Postive Control |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 4 Participants | 2 Participants | 2 Participants |
| Age, Categorical Between 18 and 65 years | 101 Participants | 53 Participants | 48 Participants |
| Age Continuous | 54.95 years STANDARD_DEVIATION 10.56 | 54.71 years STANDARD_DEVIATION 9.6 | 55.22 years STANDARD_DEVIATION 11.6 |
| Region of Enrollment Israel | 105 participants | 55 participants | 50 participants |
| Sex: Female, Male Female | 53 Participants | 29 Participants | 24 Participants |
| Sex: Female, Male Male | 52 Participants | 26 Participants | 26 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 55 | 0 / 50 |
| serious Total, serious adverse events | 0 / 55 | 0 / 50 |
Outcome results
Primary
A.Actinomycetemcomitans (DNA Probe Analysis)- Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implant. Data point is Least means square (LSM) determined by baseline adjusted means including Standard Error of Means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | A.Actinomycetemcomitans (DNA Probe Analysis)- Dental Implant | 5.664 Log cfu (colony forming units) | Standard Error 0.1222 |
| B - Postive Control | A.Actinomycetemcomitans (DNA Probe Analysis)- Dental Implant | 4.339 Log cfu (colony forming units) | Standard Error 0.1908 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
A.Actinomycetemcomitans (DNA Probe Analysis)- Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implant. Data point is Least means square (LSM) determined by baseline adjusted means including Standard Error of Means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | A.Actinomycetemcomitans (DNA Probe Analysis)- Dental Implant | 5.814 Log cfu (colony forming units) | Standard Error 0.1262 |
| B - Postive Control | A.Actinomycetemcomitans (DNA Probe Analysis)- Dental Implant | 4.446 Log cfu (colony forming units) | Standard Error 0.1589 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
A.Actinomycetemcomitans (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are Least means square (LSM)determined by baseline adjusted means including Standard Error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | A.Actinomycetemcomitans (DNA Probe Analysis) - Natural Teeth | 6.269 Log cfu (Colony Forming Units) | Standard Error 0.006 |
| B - Postive Control | A.Actinomycetemcomitans (DNA Probe Analysis) - Natural Teeth | 5.002 Log cfu (Colony Forming Units) | Standard Error 0.1117 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
A.Actinomycetemcomitans (DNA Probe Analysis)- Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data point is Least means square (LSM) determined by baseline adjusted means including Standard Error of Means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | A.Actinomycetemcomitans (DNA Probe Analysis)- Natural Teeth | 6.201 Log cfu (colony forming units) | Standard Error 0.1117 |
| B - Postive Control | A.Actinomycetemcomitans (DNA Probe Analysis)- Natural Teeth | 4.669 Log cfu (colony forming units) | Standard Error 0.1325 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Capnocytophaga sp. (DNA Probe Analysis) - Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Capnocytophaga sp. (DNA Probe Analysis) - Dental Implant | 4.391 Log cfu (colony forming units) | Standard Error 0.07532 |
| B - Postive Control | Capnocytophaga sp. (DNA Probe Analysis) - Dental Implant | 4.243 Log cfu (colony forming units) | Standard Error 0.08163 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Capnocytophaga sp. (DNA Probe Analysis) - Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Capnocytophaga sp. (DNA Probe Analysis) - Dental Implant | 4.356 Log cfu (colony forming units) | Standard Error 0.07716 |
| B - Postive Control | Capnocytophaga sp. (DNA Probe Analysis) - Dental Implant | 4.268 Log cfu (colony forming units) | Standard Error 0.08752 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Capnocytophaga sp. (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Capnocytophaga sp. (DNA Probe Analysis) - Natural Teeth | 4.676 Log cfu (colony forming units) | Standard Error 0.05921 |
| B - Postive Control | Capnocytophaga sp. (DNA Probe Analysis) - Natural Teeth | 4.526 Log cfu (colony forming units) | Standard Error 0.06476 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANOVA
Primary
Capnocytophaga sp. (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Capnocytophaga sp. (DNA Probe Analysis) - Natural Teeth | 4.644 Log cfu (colony forming units) | Standard Error 0.07209 |
| B - Postive Control | Capnocytophaga sp. (DNA Probe Analysis) - Natural Teeth | 4.411 Log cfu (colony forming units) | Standard Error 0.07971 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
C.Rectus (DNA Probe Analysis) - Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | C.Rectus (DNA Probe Analysis) - Dental Implant | 4.318 Log cfu (colony forming units) | Standard Error 0.1318 |
| B - Postive Control | C.Rectus (DNA Probe Analysis) - Dental Implant | 2.758 Log cfu (colony forming units) | Standard Error 0.2106 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
C.Rectus (DNA Probe Analysis) - Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | C.Rectus (DNA Probe Analysis) - Dental Implant | 4.46 Log cfu (colony forming units) | Standard Error 0.1226 |
| B - Postive Control | C.Rectus (DNA Probe Analysis) - Dental Implant | 3.015 Log cfu (colony forming units) | Standard Error 0.1843 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
C.Rectus (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | C.Rectus (DNA Probe Analysis) - Natural Teeth | 4.69 Log cfu (colony forming units) | Standard Error 0.1269 |
| B - Postive Control | C.Rectus (DNA Probe Analysis) - Natural Teeth | 3.322 Log cfu (colony forming units) | Standard Error 0.1548 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
C.Rectus (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | C.Rectus (DNA Probe Analysis) - Natural Teeth | 4.578 Log cfu (colony forming units) | Standard Error 0.1403 |
| B - Postive Control | C.Rectus (DNA Probe Analysis) - Natural Teeth | 2.798 Log cfu (colony forming units) | Standard Error 0.172 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
E.Corrodens (DNA Probe Analysis) - Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM)determined by baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | E.Corrodens (DNA Probe Analysis) - Dental Implant | 6.21 Log cfu (colony forming units) | Standard Error 0.148 |
| B - Postive Control | E.Corrodens (DNA Probe Analysis) - Dental Implant | 5.639 Log cfu (colony forming units) | Standard Error 0.162 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
E.Corrodens (DNA Probe Analysis) - Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM)determined by baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | E.Corrodens (DNA Probe Analysis) - Dental Implant | 6.242 Log cfu (colony forming units) | Standard Error 0.1619 |
| B - Postive Control | E.Corrodens (DNA Probe Analysis) - Dental Implant | 5.482 Log cfu (colony forming units) | Standard Error 0.1791 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
E.Corrodens (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM)determined by baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | E.Corrodens (DNA Probe Analysis) - Natural Teeth | 6.417 Log cfu (colony forming units) | Standard Error 0.1808 |
| B - Postive Control | E.Corrodens (DNA Probe Analysis) - Natural Teeth | 5.682 Log cfu (colony forming units) | Standard Error 0.1937 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
E.Corrodens (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM)determined by baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | E.Corrodens (DNA Probe Analysis) - Natural Teeth | 6.47 Log cfu (colony forming units) | Standard Error 0.1477 |
| B - Postive Control | E.Corrodens (DNA Probe Analysis) - Natural Teeth | 5.822 Log cfu (colony forming units) | Standard Error 0.1583 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
E.Saburreum (DNA Probe Analysis) - Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | E.Saburreum (DNA Probe Analysis) - Dental Implant | 5.012 Log cfu (colony forming units) | Standard Error 0.1065 |
| B - Postive Control | E.Saburreum (DNA Probe Analysis) - Dental Implant | 3.861 Log cfu (colony forming units) | Standard Error 0.1222 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
E.Saburreum (DNA Probe Analysis) - Dental Implant
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | E.Saburreum (DNA Probe Analysis) - Dental Implant | 4.733 Log cfu (colony forming units) | Standard Error 0.1287 |
| B - Postive Control | E.Saburreum (DNA Probe Analysis) - Dental Implant | 3.372 Log cfu (colony forming units) | Standard Error 0.1728 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
E.Saburreum (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | E.Saburreum (DNA Probe Analysis) - Natural Teeth | 5.229 Log cfu (colony forming units) | Standard Error 0.1199 |
| B - Postive Control | E.Saburreum (DNA Probe Analysis) - Natural Teeth | 4.385 Log cfu (colony forming units) | Standard Error 0.1328 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
E.Saburreum (DNA Probe Analysis)- Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM)detemined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | E.Saburreum (DNA Probe Analysis)- Natural Teeth | 5.079 Log cfu (colony forming units) | Standard Error 0.1424 |
| B - Postive Control | E.Saburreum (DNA Probe Analysis)- Natural Teeth | 3.571 Log cfu (colony forming units) | Standard Error 0.1655 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
F.Nucleatum (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM)determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | F.Nucleatum (DNA Probe Analysis) - Dental Implants | 4.602 Log cfu (colony forming units) | Standard Error 0.1348 |
| B - Postive Control | F.Nucleatum (DNA Probe Analysis) - Dental Implants | 2.425 Log cfu (colony forming units) | Standard Error 0.1474 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
F.Nucleatum (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM)determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | F.Nucleatum (DNA Probe Analysis) - Dental Implants | 4.89 Log cfu (colony forming units) | Standard Error 0.1277 |
| B - Postive Control | F.Nucleatum (DNA Probe Analysis) - Dental Implants | 3.637 Log cfu (colony forming units) | Standard Error 0.1354 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
F.Nucleatum (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM)determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | F.Nucleatum (DNA Probe Analysis) - Natural Teeth | 5.337 Log cfu (colony forming units) | Standard Error 0.1773 |
| B - Postive Control | F.Nucleatum (DNA Probe Analysis) - Natural Teeth | 4.403 Log cfu (colony forming units) | Standard Error 0.123 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
F.Nucleatum (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error of means (SEM)
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | F.Nucleatum (DNA Probe Analysis) - Natural Teeth | 5.243 Log cfu (colony forming units) | Standard Error 0.1265 |
| B - Postive Control | F.Nucleatum (DNA Probe Analysis) - Natural Teeth | 3.405 Log cfu (colony forming units) | Standard Error 0.1327 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Gingival Bleeding on Probing (BOP) Using Sulcus Bleeding Index for Teeth
Sulcus bleeding index for teeth is explained here. Gums around teeth are scored:0 = gingiva of normal texture & color, no bleeding;1 = gingiva normal, bleeds on probing;2 = bleeding on probing,change in color, no oedema;3 = bleeding on probing,change in color, slight oedema;4 = bleeding on probing,change in color, obvious oedema;5 = bleeding on probing, spontaneous bleeding,change in color,marked oedema.
Time frame: 6 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Gingival Bleeding on Probing (BOP) Using Sulcus Bleeding Index for Teeth | 0.877 Units on a scale | Standard Deviation 0.88 |
| B - Postive Control | Gingival Bleeding on Probing (BOP) Using Sulcus Bleeding Index for Teeth | 0.53 Units on a scale | Standard Deviation 0.76 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Gingival Bleeding on Probing (BOP) Using Sulcus Bleeding Index for Teeth
Sulcus bleeding index for teeth is explained here. Gums around teeth are scored:0 = gingiva of normal texture & color, no bleeding;1 = gingiva normal, bleeds on probing;2 = bleeding on probing,change in color, no oedema; 3 = bleeding on probing,change in color, slight oedema;4 = bleeding on probing, change in color, obvious oedema;5=bleeding on probing, spontaneous bleeding, change in color, marked oedema.
Time frame: 3 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Gingival Bleeding on Probing (BOP) Using Sulcus Bleeding Index for Teeth | 0.77 Units on a scale | Standard Deviation 0.8 |
| B - Postive Control | Gingival Bleeding on Probing (BOP) Using Sulcus Bleeding Index for Teeth | 0.51 Units on a scale | Standard Deviation 0.67 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Gingival Bleeding on Probing (BOP) Using the Modified Sulcus Bleeding Index for Implants
Gingival bleeding on probing (BOP) using the modified sulcus bleeding index for implants. Scale equals 0 = No bleeding when periodontal probe is passed along the gingival margin;1 = Isolated bleeding spots visible;2 = Blood forms a confluent red line on the gingival margin;3 = Heavy or profuse bleeding.
Time frame: 6 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Gingival Bleeding on Probing (BOP) Using the Modified Sulcus Bleeding Index for Implants | 0.81 Units on a scale | Standard Deviation 0.9 |
| B - Postive Control | Gingival Bleeding on Probing (BOP) Using the Modified Sulcus Bleeding Index for Implants | 0.45 Units on a scale | Standard Deviation 0.69 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Gingival Bleeding on Probing (BOP) Using the Modified Sulcus Bleeding Index for Implants
Gingival bleeding on probing (BOP) using the modified sulcus bleeding index for implants. Scale equals 0 = No bleeding when periodontal probe is passed along the gingival margin;1 = Isolated bleeding spots visible;2 = Blood forms a confluent red line on the gingival margin;3 = Heavy or profuse bleeding.
Time frame: 3 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Gingival Bleeding on Probing (BOP) Using the Modified Sulcus Bleeding Index for Implants | 0.65 Units on a scale | Standard Deviation 0.78 |
| B - Postive Control | Gingival Bleeding on Probing (BOP) Using the Modified Sulcus Bleeding Index for Implants | 0.48 Units on a scale | Standard Deviation 0.68 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Löe-Silness Gingival Index Score (GI)- Dental Implants
Gingivitis Score (GI) is defined: 0 = Absence of inflammation,1 = Mild inflammation-slight change in color and little change in texture,2 = Moderate inflammation-moderate glazing,redness,edema & hypertrophy,3 = Severe inflammation-marked redness and hypertrophy tendency for spontaneous bleeding. Each tooth is scored on 6 surfaces:mesio-facial;2)mid-facial;3)disto-facial;4)mesio-lingual;5)mid-lingualand 6)disto-lingual. A whole mouth score=adding all the GI scores & dividing by the total of number of sites scored. 3rd molars and teeth with restorations or crowns will be excluded.
Time frame: 6 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Löe-Silness Gingival Index Score (GI)- Dental Implants | 1.24 units on a scale | Standard Deviation 0.81 |
| B - Postive Control | Löe-Silness Gingival Index Score (GI)- Dental Implants | 0.99 units on a scale | Standard Deviation 0.73 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Löe-Silness Gingival Index Score (GI)- Dental Implants
Gingivitis Score (GI) is defined: 0 = Absence of inflammation,1=Mild inflammation-slight change in color and little change in texture,2 = Moderate inflammation-moderate glazing,redness,edema & hypertrophy,3 = Severe inflammation-marked redness and hypertrophy tendency for spontaneous bleeding. Each tooth is scored on 6 surfaces:mesio-facial;2)mid-facial;3)disto-facial;4)mesio-lingual;5)mid-lingualand 6)disto-lingual. A whole mouth score=adding all the GI scores & dividing by the total of number of sites scored. 3rd molars and teeth with restorations or crowns will be excluded.
Time frame: 3 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Löe-Silness Gingival Index Score (GI)- Dental Implants | 1.27 units on a scale | Standard Deviation 0.67 |
| B - Postive Control | Löe-Silness Gingival Index Score (GI)- Dental Implants | 1.12 units on a scale | Standard Deviation 0.63 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Löe-Silness Gingival Index Score (GI) - Natural Teeth
Gingivitis score(GI) is defined: 0 = Absence of inflammation,1 = Mild inflammation-slight change in color and little change in texture,2 = Moderate inflammation-moderate glazing,redness,edema & hypertrophy,3 = Severe inflammation-marked redness and hypertrophy tendency for spontaneous bleeding.Each tooth is scored on 6 surfaces:mesio-facial;2)mid-facial;3)disto-facial;4)mesio-lingual;5)mid-lingualand 6)disto-lingual. A whole mouth score = adding all the GI scores & dividing by the total of number of sites scored. 3rd molars and teeth with restorations or crowns will be excluded.
Time frame: 6 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Löe-Silness Gingival Index Score (GI) - Natural Teeth | 1.29 units on a scale | Standard Deviation 0.79 |
| B - Postive Control | Löe-Silness Gingival Index Score (GI) - Natural Teeth | 1.01 units on a scale | Standard Deviation 0.8 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Löe-Silness Gingival Index Score (GI) - Natural Teeth
Gingivitis score(GI) is defined: 0 = Absence of inflammation,1 = Mild inflammation-slight change in color and little change in texture,2 = Moderate inflammation-moderate glazing,redness,edema & hypertrophy,3 = Severe inflammation-marked redness and hypertrophy tendency for spontaneous bleeding. Each tooth is scored on 6 surfaces:mesio-facial;2)mid-facial;3)disto-facial;4)mesio-lingual;5)mid-lingualand 6)disto-lingual. A whole mouth score = adding all the GI scores & dividing by the total of number of sites scored. 3rd molars and teeth with restorations or crowns will be excluded.
Time frame: 3 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Löe-Silness Gingival Index Score (GI) - Natural Teeth | 1.3 units on a scale | Standard Deviation 0.73 |
| B - Postive Control | Löe-Silness Gingival Index Score (GI) - Natural Teeth | 1.17 units on a scale | Standard Deviation 0.61 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Mombelli Plaque Index (mPI) for Dental Implants
Modified Plaque Index (mPI) is a dental plaque scale as follows 0 = No plaque, 1 = Separate flecks of plaque at the cervical margin;2 = Plaque can be seen by naked eye.3 = Abundance of soft matter. The lower the number the less plaque is present on the tooth.
Time frame: 6 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Mombelli Plaque Index (mPI) for Dental Implants | 1.71 units on a scale | Standard Deviation 0.56 |
| B - Postive Control | Mombelli Plaque Index (mPI) for Dental Implants | 1.45 units on a scale | Standard Deviation 0.53 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Mombelli Plaque Index (mPI) for Dental Implants
Modified Plaque Index (mPI) is a dental plaque scale as follows 0 = No plaque, 1 = Separate flecks of plaque at the cervical margin;2 = Plaque can be seen by naked eye.3 = Abundance of soft matter. The lower the number the less plaque is present on the tooth.
Time frame: 3 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Mombelli Plaque Index (mPI) for Dental Implants | 1.62 units on a scale | Standard Deviation 0.63 |
| B - Postive Control | Mombelli Plaque Index (mPI) for Dental Implants | 1.35 units on a scale | Standard Deviation 0.48 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Mombelli Plaque Index (mPI) for Natural Teeth
Modified Plaque Index (mPI)is a Dental plaque scale as follows 0 = No plaque, 1 = Separate flecks of plaque at the cervical margin;2 = Plaque can be seen by naked eye.3 = Abundance of soft matter. The lower the number the less plaque is present on the tooth.
Time frame: 3 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Mombelli Plaque Index (mPI) for Natural Teeth | 1.96 units on a scale | Standard Deviation 0.63 |
| B - Postive Control | Mombelli Plaque Index (mPI) for Natural Teeth | 1.82 units on a scale | Standard Deviation 0.62 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Mombelli Plaque Index (mPI) for Natural Teeth
Modified Plaque Index (mPI) is a Dental plaque scale as follows 0 = No plaque, 1 = Separate flecks of plaque at the cervical margin;2 = Plaque can be seen by naked eye.3 = Abundance of soft matter. The lower the number the less plaque is present on the tooth.
Time frame: 6 months
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Mombelli Plaque Index (mPI) for Natural Teeth | 2.05 units on a scale | Standard Deviation 0.59 |
| B - Postive Control | Mombelli Plaque Index (mPI) for Natural Teeth | 1.73 units on a scale | Standard Deviation 0.68 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Neissera sp. (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Neissera sp. (DNA Probe Analysis) - Dental Implants | 4.585 Log cfu (colony forming units) | Standard Error 0.1546 |
| B - Postive Control | Neissera sp. (DNA Probe Analysis) - Dental Implants | 4.415 Log cfu (colony forming units) | Standard Error 0.2199 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Neissera sp. (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Neissera sp. (DNA Probe Analysis) - Dental Implants | 4.405 Log cfu (colony forming units) | Standard Error 0.1151 |
| B - Postive Control | Neissera sp. (DNA Probe Analysis) - Dental Implants | 3.955 Log cfu (colony forming units) | Standard Error 0.1193 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Neissera sp. (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Neissera sp. (DNA Probe Analysis) - Natural Teeth | 4.638 Log cfu (colony forming units) | Standard Error 0.1203 |
| B - Postive Control | Neissera sp. (DNA Probe Analysis) - Natural Teeth | 4.508 Log cfu (colony forming units) | Standard Error 0.1336 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Neissera sp. (DNA Probe Analysis) Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points least means square (LSM) determined by baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Neissera sp. (DNA Probe Analysis) Natural Teeth | 4.702 Log cfu (colony forming units) | Standard Error 0.1301 |
| B - Postive Control | Neissera sp. (DNA Probe Analysis) Natural Teeth | 4.658 Log cfu (colony forming units) | Standard Error 0.1604 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Gingivalis (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error of means (SEM)
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Gingivalis (DNA Probe Analysis) - Dental Implants | 5.784 Log cfu (colony forming units) | Standard Error 0.1533 |
| B - Postive Control | P.Gingivalis (DNA Probe Analysis) - Dental Implants | 4.926 Log cfu (colony forming units) | Standard Error 0.1789 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Gingivalis (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error of means (SEM)
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Gingivalis (DNA Probe Analysis) - Dental Implants | 5.562 Log cfu (colony forming units) | Standard Error 0.1995 |
| B - Postive Control | P.Gingivalis (DNA Probe Analysis) - Dental Implants | 4.642 Log cfu (colony forming units) | Standard Error 0.2578 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Gingivalis (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error of means (SEM)
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Gingivalis (DNA Probe Analysis) - Natural Teeth | 6.166 Log cfu (colony forming units) | Standard Error 0.1438 |
| B - Postive Control | P.Gingivalis (DNA Probe Analysis) - Natural Teeth | 5.183 Log cfu (colony forming units) | Standard Error 0.1705 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Gingivalis (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM)
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Gingivalis (DNA Probe Analysis) - Natural Teeth | 6.071 Log cfu (colony forming units) | Standard Error 0.1675 |
| B - Postive Control | P.Gingivalis (DNA Probe Analysis) - Natural Teeth | 4.951 Log cfu (colony forming units) | Standard Error 0.2125 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Intermedia (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Intermedia (DNA Probe Analysis) - Dental Implants | 4.544 Log cfu (colony forming units) | Standard Error 0.1555 |
| B - Postive Control | P.Intermedia (DNA Probe Analysis) - Dental Implants | 3.853 Log cfu (colony forming units) | Standard Error 0.2115 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Intermedia (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Intermedia (DNA Probe Analysis) - Dental Implants | 4.329 Log cfu (colony forming units) | Standard Error 0.1617 |
| B - Postive Control | P.Intermedia (DNA Probe Analysis) - Dental Implants | 3.803 Log cfu (colony forming units) | Standard Error 0.3178 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Intermedia (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Intermedia (DNA Probe Analysis) - Natural Teeth | 5.091 Log cfu (colony forming units) | Standard Error 0.1526 |
| B - Postive Control | P.Intermedia (DNA Probe Analysis) - Natural Teeth | 3.853 Log cfu (colony forming units) | Standard Error 0.1824 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Intermedia (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Intermedia (DNA Probe Analysis) - Natural Teeth | 5.007 Log cfu (colony forming units) | Standard Error 0.1499 |
| B - Postive Control | P.Intermedia (DNA Probe Analysis) - Natural Teeth | 3.803 Log cfu (colony forming units) | Standard Error 0.1875 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Melaninogenica (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Melaninogenica (DNA Probe Analysis) - Dental Implants | 4.406 Log cfu (colony forming units) | Standard Error 0.0982 |
| B - Postive Control | P.Melaninogenica (DNA Probe Analysis) - Dental Implants | 3.363 Log cfu (colony forming units) | Standard Error 0.11309 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Melaninogenica (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Melaninogenica (DNA Probe Analysis) - Dental Implants | 4.387 Log cfu (colony forming units) | Standard Error 0.1131 |
| B - Postive Control | P.Melaninogenica (DNA Probe Analysis) - Dental Implants | 3.155 Log cfu (colony forming units) | Standard Error 0.1303 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Melaninogenica (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for both natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Melaninogenica (DNA Probe Analysis) - Natural Teeth | 5.062 Log cfu (colony forming units) | Standard Error 0.1141 |
| B - Postive Control | P.Melaninogenica (DNA Probe Analysis) - Natural Teeth | 3.691 Log cfu (colony forming units) | Standard Error 0.1252 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
P.Melaninogenica (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | P.Melaninogenica (DNA Probe Analysis) - Natural Teeth | 5.066 Log cfu (colony forming units) | Standard Error 0.1067 |
| B - Postive Control | P.Melaninogenica (DNA Probe Analysis) - Natural Teeth | 3.935 Log cfu (colony forming units) | Standard Error 0.1171 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Solobacterium (S.Moorei)(DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Solobacterium (S.Moorei)(DNA Probe Analysis) - Dental Implants | 5.767 Log cfu (colony forming units) | Standard Error 0.0346 |
| B - Postive Control | Solobacterium (S.Moorei)(DNA Probe Analysis) - Dental Implants | 4.701 Log cfu (colony forming units) | Standard Error 0.02777 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Solobacterium (S.Moorei)(DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Solobacterium (S.Moorei)(DNA Probe Analysis) - Dental Implants | 5.046 Log cfu (colony forming units) | Standard Error 0.3545 |
| B - Postive Control | Solobacterium (S.Moorei)(DNA Probe Analysis) - Dental Implants | 3.899 Log cfu (colony forming units) | Standard Error 0.4863 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Solobacterium (S.Moorei)(DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Solobacterium (S.Moorei)(DNA Probe Analysis) - Natural Teeth | 6.511 Log cfu (colony forming units) | Standard Error 0.1553 |
| B - Postive Control | Solobacterium (S.Moorei)(DNA Probe Analysis) - Natural Teeth | 5.237 Log cfu (colony forming units) | Standard Error 0.1608 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Solobacterium (S.Moorei)(DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Solobacterium (S.Moorei)(DNA Probe Analysis) - Natural Teeth | 6.081 Log cfu (colony forming units) | Standard Error 0.2425 |
| B - Postive Control | Solobacterium (S.Moorei)(DNA Probe Analysis) - Natural Teeth | 4.487 Log cfu (colony forming units) | Standard Error 0.2476 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Streptococci (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means )SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Streptococci (DNA Probe Analysis) - Dental Implants | 4.665 Log cfu (colony forming units) | Standard Error 0.1431 |
| B - Postive Control | Streptococci (DNA Probe Analysis) - Dental Implants | 2.404 Log cfu (colony forming units) | Standard Error 0.1503 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Streptococci (DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means )SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Streptococci (DNA Probe Analysis) - Dental Implants | 5 Log cfu (colony forming units) | Standard Error 0.1317 |
| B - Postive Control | Streptococci (DNA Probe Analysis) - Dental Implants | 3.263 Log cfu (colony forming units) | Standard Error 0.1383 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Streptococci (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means )SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Streptococci (DNA Probe Analysis) - Natural Teeth | 5.995 Log cfu (colony forming units) | Standard Error 0.1175 |
| B - Postive Control | Streptococci (DNA Probe Analysis) - Natural Teeth | 4.495 Log cfu (colony forming units) | Standard Error 0.1234 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Streptococci (DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Streptococci (DNA Probe Analysis) - Natural Teeth | 5.867 Log cfu (colony forming units) | Standard Error 0.1195 |
| B - Postive Control | Streptococci (DNA Probe Analysis) - Natural Teeth | 4.109 Log cfu (colony forming units) | Standard Error 0.1255 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
T.Forsythia (DNA Probe Analysis)- Dental Implants
14 microorganisms were identified via DNA probe analysis for both Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | T.Forsythia (DNA Probe Analysis)- Dental Implants | 6.08 Log cfu (colony forming units) | Standard Error 0.1691 |
| B - Postive Control | T.Forsythia (DNA Probe Analysis)- Dental Implants | 4.633 Log cfu (colony forming units) | Standard Error 0.2153 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
T.Forsythia (DNA Probe Analysis)- Dental Implants
14 microorganisms were identified via DNA probe analysis for both Dental Implants. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | T.Forsythia (DNA Probe Analysis)- Dental Implants | 6.19 Log cfu (colony forming units) | Standard Error 0.1637 |
| B - Postive Control | T.Forsythia (DNA Probe Analysis)- Dental Implants | 4.628 Log cfu (colony forming units) | Standard Error 0.1831 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
T.Forsythia (DNA Probe Analysis)- Natural Teeth
14 microorganisms were identified via DNA probe analysis for both natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | T.Forsythia (DNA Probe Analysis)- Natural Teeth | 6.408 Log cfu (colony forming units) | Standard Error 0.1348 |
| B - Postive Control | T.Forsythia (DNA Probe Analysis)- Natural Teeth | 5.143 Log cfu (colony forming units) | Standard Error 0.1474 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
T.Forsythia (DNA Probe Analysis)-Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error of means (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | T.Forsythia (DNA Probe Analysis)-Natural Teeth | 6.286 Log cfu (colony forming units) | Standard Error 0.1628 |
| B - Postive Control | T.Forsythia (DNA Probe Analysis)-Natural Teeth | 4.926 Log cfu (colony forming units) | Standard Error 0.182 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Veillonella sp.(DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error (SEM)
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Veillonella sp.(DNA Probe Analysis) - Dental Implants | 5.472 Log cfu (colony forming units) | Standard Error 0.1408 |
| B - Postive Control | Veillonella sp.(DNA Probe Analysis) - Dental Implants | 4.485 Log cfu (colony forming units) | Standard Error 0.1494 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Veillonella sp.(DNA Probe Analysis) - Dental Implants
14 microorganisms were identified via DNA probe analysis for Dental Implants. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error (SEM)
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Veillonella sp.(DNA Probe Analysis) - Dental Implants | 5.364 Log cfu (colony forming units) | Standard Error 0.1425 |
| B - Postive Control | Veillonella sp.(DNA Probe Analysis) - Dental Implants | 4.186 Log cfu (colony forming units) | Standard Error 0.1511 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Veillonella sp.(DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) detemined by using baseline adjusted means including standard error (SEM)
Time frame: 3 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Veillonella sp.(DNA Probe Analysis) - Natural Teeth | 5.82 Log cfu (colony forming units) | Standard Error 0.1185 |
| B - Postive Control | Veillonella sp.(DNA Probe Analysis) - Natural Teeth | 4.927 Log cfu (colony forming units) | Standard Error 0.1245 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA
Primary
Veillonella sp.(DNA Probe Analysis) - Natural Teeth
14 microorganisms were identified via DNA probe analysis for natural teeth. Data points are least means square (LSM) determined by using baseline adjusted means including standard error (SEM).
Time frame: 6 months
| Arm | Measure | Value (LEAST_SQUARES_MEAN) | Dispersion |
|---|---|---|---|
| A - Fluoride Control | Veillonella sp.(DNA Probe Analysis) - Natural Teeth | 5.746 Log cfu (colony forming units) | Standard Error 0.1282 |
| B - Postive Control | Veillonella sp.(DNA Probe Analysis) - Natural Teeth | 4.563 Log cfu (colony forming units) | Standard Error 0.1346 |
Comparison: The null hypothesis states that there is no difference between groups.p-value: 0.05ANCOVA