Acute Coronary Syndrome
Conditions
Keywords
IVUS-VH, Plaque characterization, Omega3-fatty acid, Atorvastatin
Brief summary
The purpose of this study is to determine whether intensive lipid lowering and Omega-3 fatty acid are effective in the treatment of coronary atherosclerotic plaque.
Interventions
DRUGIntensive lipid lowering plus Omega3-fatty acid
Atorvastatin 40mg qd plus Omega3-fatty acid 2.0mg qd
DRUGModerate lipid lowering plus Omega3-fatty acid
atorvastatin 10mg qd plus Omega3-fatty acid 2.0mg qd
DRUGIntensive lipid lowering plus placebo
atorvastatin 40mg qd
DRUGModerate lipid lowering plus placebo
atorvastatin 10mg qd
Sponsors
Samsung Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Acute coronary syndrome within 48 hours of symptom onset * Have de novo non-culprit coronary artery stenosis 20% to 70% by visual estimation
Exclusion criteria
* Cardiogenic shock * ST segment elevation myocardial infarction within 1 week * Hematologic disorder: neutropenia (neutrophil\<3000/mm3), thrombocytopenia (platelet\<100,000/mm3) * Liver enzyme elevation: serum aspartate aminotransferase or alanine aminotransferase concentrations more than 3 times the upper limit of normal * Impaired renal function with serum creatinine \> 2mg/dL * Bleeding diathesis or history of coagulopathy * Pregnancy * Hypersensitivity to heparin, dye, aspirin, clopidogrel, statin, or fish
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plaque stabilization using serial virtual histology intravascular ultrasound analysis | 1 year |
Countries
South Korea
Contacts
Primary ContactHyeon-Cheol Gwon, Professor
Outcome results
None listed