Adipose Tissue Inflammation, Morbid Obesity
Conditions
Brief summary
Inflammation in the adipose (fat) tissue is an important condition leading to metabolic derangements and cardiovascular disease in obese patients. n-3 polyunsaturated fatty acids exert anti-inflammatory effects and prevent adipose tissue inflammation in rodent obesity. This study tests the hypothesis that n-3 polyunsaturated fatty acids ameliorate adipose tissue inflammation in morbidly obese patients.
Interventions
DRUGreesterified long-chain n-3 polyunsaturated fatty acids (EPA, DHA)
4g daily, 8 weeks
DRUGcontrol
equivalent amount of fat as butter
Sponsors
National Bank of Austria
Medical University of Vienna
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Non-diabetic morbidly obese patients (BMI \> 40 kg/m2) supposed to undergo bariatric surgery * Age 20-65 yrs
Exclusion criteria
* Acute illness within the last two week * Known diabetes mellitus or current anti-diabetic medication * Acquired immunodeficiency (HIV infection) * Hepatitis or other significant liver disease * Severe or untreated cardiovascular, renal, pulmonary disease * Untreated or inadequately treated clinically significant thyroid disease * Anemia * Active malignant disease * Inborn or acquired bleeding disorder including warfarin treatment * Pregnancy or breast feeding * Drug intolerability that prohibits the use of the study drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adipose tissue inflammation | Eight weeks of treatment |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic control | Eight weeks of treatment |
| Dependence of effects on Pparg polymorphisms | Eight weeks of treatment |
Countries
Austria
Outcome results
None listed