Coronary Artery Disease
Conditions
Keywords
abnormal stress test, fractional flow reserve, pressure drop coefficient, lesion flow coefficient
Brief summary
Newly developed diagnostic parameters have potential to differentiate between epicardial disease and microvascular dysfunction with the help of anatomical details and physiological endpoints and can be used in present clinical settings.
Detailed description
The pressure drop coefficient (CDP) is a functional index based on hyperemic dp and u measurements. The lesion flow coefficient (LFC) combines the functional index CDP with an atomic measure (percentage area stenosis) as a single parameter.
Interventions
DEVICEFFR/CFR and IVUS
All patients with clinical indication for cardiac cath will have FFR and IVUS
Sponsors
University of Cincinnati
American Heart Association
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Abnormal Myocardial stress perfusion (SPECT) LV EF \> 25% * 18 years of age or above * Patients referred to a stress test by a Cardiologist * Acute Chest pain, as per patient input. * Risk Assessment with prior test results and/or previous history of known chronic stable CAD. * Borderline or discordant stress testing where obstructive CAD remains a concern. * New or worsening symptoms- Abnormal coronary angiography or abnormal prior stress imaging study. * Coronary stenosis or anatomic abnormality of uncertain significance. * In absence of reliable diagnostic information from another imaging modality.
Exclusion criteria
* Serum Creatinine \> 2.5 gm/dL * Type II HIT * Left ventricular ejection fraction less the 25% determined by gated SPECT imaging ( - LV \< or + to 25%) * Non-dialysis dependent chronic kidney disease with baseline serum creatinine greater than 2.5 gm/dL. * History of type II heparin-induced thrombocytopenia. * Significant co-morbid condition that is medically unstable and would make coronary angiography prohibitive or contraindicated. * Pregnant women. * Incapacitated for Consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to detect ischemic heart disease in patients with abnormal stress tests using MPI with SPECT and to determine the presence of significant epicardial stenosis using coronary angiography with simultaneous physiological pressure and flow measurements | Upon Diagnostic Angiogram and Flow Wire |
Secondary
| Measure | Time frame |
|---|---|
| To compare novel measurements, Pressure Drop Coefficient (CDP) & Lesion Flow Coefficient (LFC), against measured current parameters called Fractional flow reserve (FFR) & Coronary flow reserve (CFR). | Upon Diagnostic Angiogram and Flow Wire |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMohamed Effat, MD
University of Cincinnati
PRINCIPAL_INVESTIGATORKranthi K Kolli, MS
University of Cincinnati
PRINCIPAL_INVESTIGATORMassoud Leesar, MD
University of Cincinnati
PRINCIPAL_INVESTIGATORRupak Banerjee, PhD
University of Cincinnati
PRINCIPAL_INVESTIGATORTarek Helmy, MD
University of Cincinnati
PRINCIPAL_INVESTIGATORSrikara Pellukhana, BS
University of Cincinnati
Outcome results
None listed