Long Term Follow up of a Cohort of Children With TCF2 Mutation:Evolution of Endocrine and Renal Function

A Long Term Follow up of a Cohort of Children With TCF2 Mutation:Evolution of Endocrine and Renal Function

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00760331

Acronym

TCF2

Enrollment

100

Registered

2008-09-26

Start date

2008-06-30

Completion date

2033-12-31

Last updated

2018-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocyte Nuclear Factor 1-beta

Keywords

HNF1B, TCF2, MODY-5, CAKUT, Anomaly of renal development

Brief summary

Anomalies of renal development are well know for patients treated for MODY-5 diabetes due to TCF2 mutation.A recent study confirms the existence of pediatric patients having TCF2 mutation but presenting renal anomalies alone.Endocrine and renal evolution of these patients is unknown.The aim of this study is to follow a cohort of patients with TCF2 mutation and initially presenting renal anomalies alone.

Detailed description

Biologic analysis and renal ultrasonography once a year. After puberty or before kidney transplantation * Abdominal and pelvic MRI * Intravenous Glucose Tolerance Test

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 18 Years

Healthy volunteers

Inclusion criteria

* Patients presenting an anomaly of renal development due to TCF2 mutation * Age\<18 years old

Exclusion criteria

* Anomaly of renal development without TCF2 mutation * Age≥18 years old * Parents or patients refusing to participate to the study

Countries

France

Outcome results