Non Small Cell Lung Carcinoma
Conditions
Keywords
Non small cell lung carcinoma, PET scan, Observational study, Non metastatic, treated, curative intent
Brief summary
The primary aim of this non interventional study is to assess the independent prognostic role on overall survival of primary tumour 18F-FDG uptake value (SUVmax) measured on 18fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in patients with non-metastatic non-small cell lung cancers treated with curative intent, taking into account the other conventional prognostic factors (performance status, age, sex, disease stage).
Interventions
None listed
Sponsors
European Lung Cancer Working Party
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Pathologically demonstrated NSCLC * Stage I-III treated by curative treatment by surgery with or without chemotherapy (induction or adjuvant) or by chemoradiotherapy * Inoperable patients treated by exclusive radiotherapy * A whole-body (skull base to mid thighs) FDG-PET or a combined FDG-PET/CT on a dedicated machine, performed before any anticancer treatment * FDG-PET or combined FDG-PET/CT has to be previously standardised according to the procedure described in appendix IV * Written informed consent * Accessibility to follow-up * Age \> 18 years
Exclusion criteria
* Prior anticancer treatment (surgery, radiotherapy or chemotherapy) * Stage IV NSCLC * A history of prior malignant tumour, except non-melanoma skin cancer or in situ carcinoma of the cervix and cured malignant tumour (more than 5-year disease free interval) * Uncontrolled diabetes mellitus (fast glycaemia above 130 mg/dl) * Pregnancy and lactating woman * Unavailability to send a copy of the PET or PET-CT (DICOM format) to the data centre
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival | Survival will be dated from the date of PET scan |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival | Period between the date of PET scan and the date of first progression or death |
Other
| Measure | Time frame |
|---|---|
| discriminant value of 18F-FDG uptake for survival and for PFS | dated from PET examination |
Countries
Belgium
Outcome results
None listed