Evaluation of Aging, Autonomic Nervous System Activity and Cardiovascular Events

Conditions

Healthy

Keywords

Aging, cardiovascular risk factors, Autonomic nervous system, stroke, Myocardiac infarction, Neuropsychological evaluation, Prospective cohort

Brief summary

The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity. Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population. This PROOF study was hence designed to evaluate ANS activity levels among a healthy retired population, but should these levels decline overtime, to use this as a predictor of cardiovascular and cerebrovascular events, taking into account established cardiovascular risk factors.

Detailed description

The main goal of this PROOF study is to evaluate, on a selected prospective cohort of subjects aged 65 years upon study entry, the prognostic values of ANS activity levels measured at preset times, and more specifically, of its decline over the follow-up period, for fatal and non-fatal cardiovascular and cerebrovascular events.

David Hupin, Jérémy Raffin, Nathalie Barth, Mathieu Berger, Martin Garet et al. (11 authors)

Frontiers in Public Health2019-03-1913 citations

10.3389/fpubh.2019.00051

Serum lipid profile, sleep-disordered breathing and blood pressure in the elderly: a 10-year follow-up of the PROOF-SYNAPSE cohort.

Monneret D, Barthélémy JC, Hupin D, Maudoux D, Celle S, Sforza E, Roche F.

2017-09-189 citations

10.1016/j.sleep.2017.07.028

Association of self-reported sleep and hypertension in non-insomniac elderly subjects.

Sforza E, Saint Martin M, Barthelemy JC, Roche F.

2014-09-1517 citations

10.5664/jcsm.4026

Sympathetic overactivity due to sleep fragmentation is associated with elevated diurnal systolic blood pressure in healthy elderly subjects: the PROOF-SYNAPSE study

Florian Chouchou, Vincent Pichot, Jean‐Louis Pépin, Renaud Tamisier, Sylvain Celle et al. (11 authors)

European Heart Journal2013-06-11127 citations

10.1093/eurheartj/eht208

Can maintaining cognitive function at 65 years old predict successful ageing 6 years later? The PROOF study.

Castro-Lionard K, Thomas-Antérion C, Crawford-Achour E, Rouch I, Trombert-Paviot B, Barthélémy JC, Laurent B, Roche F, Gonthier R.

2011-01-2022 citations

10.1093/ageing/afq174

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* 65 years old * informed consent signed

Exclusion criteria

* prior myocardiac infarction * prior stroke * hearth failure * atrial fibrillation * insulin-treated diabetes mellitus * cardiac pacemaker * disease limiting life expectancy to \< 5 years * contraindication to brain MRI * living in an institution

Design outcomes

Primary

Measure	Time frame
Composite criterion : fatal and non-fatal cardiovascular or cerebrovascular events	During all the study

Secondary

Measure	Time frame
Presence and severity of clinically silent stroke revealed through brain MRI	Years 1, 3 and 5
Neuropsychological performance	Years 1, 3 and 5
ANS activity measured by heart rate variability + spontaneous baroreflex + blood pressure variability	Years 1, 3 and 5
Biological data : fasting blood glucose, total and HDL cholesterol, triglycerides and CRP	Years 1, 3 and 5

Countries

France

Outcome results