Effect of Stress on Heroin-Related Memory Retrieval

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00759005

Enrollment

Unknown

Registered

2008-09-25

Start date

2007-03-31

Completion date

2008-09-30

Last updated

2008-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heroin Dependence, Learning and Memory

Brief summary

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Interventions

DRUGpropranolol and cortisol

Eligibility

Sex/Gender

MALE

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion criteria

* current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Design outcomes

Primary

Measure	Time frame
Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts	—

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026