Blood Samples From Healthy Volunteers for Genetic Studies in the East Anglia Region of the United Kingdom

A Population Based Control Collection for Genetic Studies in East Anglia

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00757991

Enrollment

4000

Registered

2008-09-23

Start date

2008-02-29

Completion date

Unknown

Last updated

2013-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, no Evidence of Disease

Keywords

healthy, no evidence of disease

Brief summary

RATIONALE: Studying samples of blood from healthy volunteers in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in healthy volunteers.

Detailed description

OBJECTIVES: * To obtain blood samples and simple epidemiological information on a population-based series of adult individuals without cancer. * To establish whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer by comparing the frequency of alterations in these genes with the corresponding frequency in a comparable series of cancer patients. * To examine the interactions between genetic and non-genetic risk factors. OUTLINE: This is a multicenter study. Participants complete a simple epidemiological questionnaire. Participants undergo blood sample collection. DNA is extracted from these samples for polymorphism analysis of low penetrance cancer susceptibility genes in the following related clinical trials: MREC-SEARCH-CANCER, MREC-SEARCH-PROSTATE, and MREC-SEARCH-BREAST. They may also be used in the analyses of the following related clinical trials: MREC-SEARCH-OVARIAN, MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL. PROJECTED ACCRUAL: A total of 2,000 male and 2,000 female participants will be accrued for this study.

Interventions

GENETICpolymorphism analysis

OTHERlaboratory biomarker analysis

OTHERquestionnaire administration

Eligibility

Sex/Gender

ALL

Age

35 Years to 69 Years

Healthy volunteers

Yes

Inclusion criteria

DISEASE CHARACTERISTICS: * Cancer-free participants randomly selected from the age-sex registry of a general practice in the East Anglia region of the United Kingdom * Two general practices from each district within East Anglia participate (up to 10 total participating practices) PATIENT CHARACTERISTICS: * Identified by the participant's general practitioner as fit to contact for this study * No prior diagnosis of cancer * No serious mental illness or retardation PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

Measure	Time frame
Acquisition of blood samples and epidemiological information	—
Investigation of whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of cancer	—
Examination of the interactions between genetic and nongenetic risk factors	—

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026