Polycystic Ovary Syndrome
Conditions
Keywords
skin blood flow, microcirculation
Brief summary
The scientific aims of the study are to determine how peripheral microcirculatory responsiveness is altered in obese women with Polycystic Ovary Syndrome (PCOS) during local heating and to determine the mechanism for testosterone effects on peripheral microcirculatory responsiveness in women with PCOS.
Detailed description
In these studies, we propose to use the skin as a relatively non-invasive model to examine cardiovascular and endothelial function in obese women with and without PCOS. Data have indicated an important role for testosterone in influencing the peripheral microcirculation. While testosterone can lead to vasodilation in the peripheral microcirculation in both men and in women without PCOS, testosterone appears to induce vasoconstriction in women with PCOS. The differential response between women with and without PCOS, and between men and women may be the result of differential ET-1 actions in the vessel, and regulated by the receptor subtype is involved in these actions.
Interventions
GnRH antagonist, subcutaneous injection, 0.25 mg/day for 21 days
DRUGmethyl testosterone
testosterone, oral administration, day 5 of GnRH administration, 2.5 mg/day
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Yale University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Obese women (18-35) years with and without PCOS
Exclusion criteria
* Conditions that would preclude safe use of hormones
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin blood flow and cutaneous vascular conductance | 6 non consecutive days |
Countries
United States
Outcome results
None listed