Systemic Lupus Erythematosus in Gullah Health

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00756769

Acronym

SLEIGH

Enrollment

750

Registered

2008-09-22

Start date

2003-04-01

Completion date

2028-06-01

Last updated

2026-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic Lupus Erythematosus

Keywords

African Americans

Brief summary

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, multiple organ involvement, and diverse clinical symptoms and immunologic manifestations. African Americans are at a disproportionately higher risk of developing SLE, develop SLE at an earlier age, and have increased morbidity and mortality compared with European Americans. Our central study hypothesis is that there are specific genetic factors that interact with environmental exposures leading to the development of SLE. The African American Gullah population from the Sea Islands of South Carolina and Georgia are unique in their genetic homogeneity with minimal non-African genetic admixture, making them an ideal cohort to address questions of environmental and genetic influence on the development and progression of SLE.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

2 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age 2 years and above; * Self-identified as African-American "Gullah" from the Sea Island region of South Carolina; * Have had at least 4 of the 11 diagnostic criteria for SLE as designated by the American College of Rheumatology (ACR), be a relative of a known SLE patient, or be an unrelated healthy Gullah control; * Ability to speak and understand English; * Ability and willingness to give informed consent

Exclusion criteria

* Race defined by participant as other than Black or African-American; * Being a prisoner, mentally ill patient, or institutionalized individual; * Unwilling or unable to give informed consent

Countries

United States

Contacts

CONTACTDiane L. Kamen, MD, MSCR

kamend@musc.edu843-792-4825

PRINCIPAL_INVESTIGATORDiane L. Kamen, MD, MSCR

Medical University of South Carolina

Outcome results