Endothelial Progenitor Cells Numbers, Endothelial Function (FMD)
Conditions
Brief summary
Light-to-moderate alcohol consumption has been associated with a reduction of cardiovascular events, and red wine seems to offer more benefits than any other type of alcoholic beverages. However, the relationship between red wine consumption and endothelial progenitor cells (EPCs) remains unclear. The investigators examine whether intake of red wine could enhance the number or functional capacity of circulating EPCs by upregulation of nitric oxide (NO) bioavailability.
Detailed description
Moderate ethanol intake from any type of beverage has been shown to improve lipoprotein metabolism and lower cardiovascular mortality risk, but red wine, with its abundant antioxidant contents, seems to confer additional healthy benefits. Previous studies indicated that the beneficial effects of red wine are derived from increased endothelium-derived nitric oxide (NO), implying that enhanced NO bioavailability may mediate the cardiovascular protection provided by red wine. Increasing evidence suggests that the injured endothelial monolayer is regenerated partly by circulating bone marrow derived-endothelial progenitor cells (EPCs), which accelerate reendothelialization and protect against the initiation and progression of atherosclerosis. Clinical studies demonstrated that the number of circulating EPCs predicts the occurrence of cardiovascular events and death from cardiovascular causes and may help to identify patients at increased cardiovascular risk. Although many epidemiologic studies have indicated that light-to-moderate consumption of red wine can reduce the incidence of CAD, the multifarious effects of red wine on circulating EPCs and endothelial function remain to be determined. Therefore, we design this study to test the hypothesis that intake of red wine can enhance the number and functional capacity of EPCs through increasing NO bioavailability.
Interventions
OTHERred wine
One group (n=20) that consumed red wine (100 ml) daily for 3 weeks Another group (n=20) that consumed beer (250 ml) daily for 3 weeks
Sponsors
National Yang Ming Chiao Tung University
Taipei Veterans General Hospital, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Forty young healthy subjects with no cardiovascular risk factors
Exclusion criteria
* History of hypertension * Diabetes mellitus * Symptoms of CAD * Smoking * Chronic renal insufficiency (serum creatinine \> 1.5 mg/dl) * Inflammatory or liver diseases * Regular alcohol consumption (drinking more than 20 g of ethanol per week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of endothelial progenitor cells, endothelial function (FMD) | VGH-97DHA0100127 |
Secondary
| Measure | Time frame |
|---|---|
| Plasma NO, hsCRP, ADMA, TNF-a, adiponectin, ox-LDL levels | VGH-97DHA0100127 |
Countries
Taiwan
Outcome results
None listed