Head Elevation in Prone Position

Influence of Head Elevation in Prone Position on Gas Exchange and Lung Mechanics in Patients With ALI/ARDS

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00753129

Enrollment

Registered

2008-09-16

Start date

2008-10-31

Completion date

2010-04-30

Last updated

2010-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gas Exchange, Lung Mechanics

Keywords

Prone position, ALI/ARDS, Head elevation

Brief summary

Semi-recumbent position leads to improvement of gas exchange and lung mechanics in patients suffering from ALI or ARDS. Prone positioning leads to similar effects. To date, no data on the combination of these two positioning measures exist. The investigators hypothesize that head elevation in prone position leads to improvement in gas exchange and lung mechanics.

Interventions

PROCEDUREProne position with head elevation

Head elevation of 30° in prone position (Ant-Trendelenburg position of the whole bed)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 89 Years

Healthy volunteers

Inclusion criteria

* Mechanically ventilated * ALI or ARDS * No contraindications for prone position

Exclusion criteria

* Patient \< 18 or \> 89 years old * Pregnancy * Elevated intracranial pressure * PaO2/FiO2 - ratio \< 60 * ECMO * Open abdomen * Instable spine * Malignant arrhythmias * Severe hemodynamic instability

Design outcomes

Primary

Measure	Time frame
PaO2/FiO2 ratio	Study period (5 hours on 2 consecutive days)

Secondary

Measure	Time frame
PaCO2, Compliance (Chest wall, lung, respiratory system)	Study period (5 hours on 2 consecutive days)

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 28, 2026