Recovery Time From Isoflurane Anesthesia in Obese Patients
Conditions
Keywords
Isocapnic hyperpnoea, obesity, isoflurane, Recovery of obese patient from isoflurane anesthesia
Brief summary
Faster recovery from anesthesia is important for obese patients because they are at high risk of respiratory complications following tracheal extubation. Isoflurane has several properties that make it a preferable agent for anesthesia in obese patients. Its main limitation is a longer recovery time due to slower elimination in comparison to other agents. Elimination of isoflurane from the lungs can be accelerated by increasing in patient's minute ventilation, which decreases the level of CO2 in blood (hypocapnia).Isocapnic Hyperpnoea (IH) is a method allowing increased ventilation and therefore enhancement of the elimination of inhalation agents while maintaining a normal blood CO2 level. The investigators will compare recovery time from isoflurane anesthesia in obese patients during standard anesthesia management protocol (control) to a group treated with IH.
Interventions
OTHERIsocapnic Hyperpnoea
IH is a method of increasing alveolar ventilation (Va) while preventing the unwanted hypocapnia by addition of CO2 to the inhaled mixture.
Sponsors
The Physicians' Services Incorporated Foundation
University Health Network, Toronto
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Elective gynecological or urological procedure, * BMI \> 35 kg/m², * ASA I-III, * Signed informed consent.
Exclusion criteria
* Lack of informed consent, * ASA IV-V, * Contra-indications to isoflurane anesthesia or other anesthetics included in the protocol, * History of cardiac or respiratory disease, * Alcohol or drug abuse, * Psychiatric illness and/or medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time from the end of anesthesia (turning isoflurane vaporizer off) to the readiness for Post Anesthesia Care Unit (PACU) discharge. | Intraoperatively and Post Anesthetic Care Unit |
Secondary
| Measure | Time frame |
|---|---|
| Times from end of anesthesia to BIS exceeds 75, b) eye-opening to verbal command, c) extubation, d) readiness for leaving | Intraoperatively and Post Anesthetic Care Unit |
| Sedation/Pain scores in the PACU. | Intraoperatively and Post Anesthetic Care Unit |
| Change in exhaled isoflurane concentrations in the 1st hour postoperatively. | Intraoperatively and Post Anesthetic Care Unit |
Countries
Canada
Outcome results
None listed