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Uremic Toxins in the Intensive Care Units (ICU): Patients With Lactate Acidosis

Study of the Kinetics of Uremic Toxins in the ICU Patients With Acute Renal Failure, in Order to Optimize the Dialysis Dose: Patients With Lactate Acidosis

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00752453
Enrollment
8
Registered
2008-09-15
Start date
2008-07-31
Completion date
2013-12-31
Last updated
2022-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Renal Failure

Keywords

ICU, patients, lactate, acidosis

Brief summary

Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with lactate acidosis. The sampling of blood and dialysate will be done during dialysis with different durations (4, 6 and 8 h)

Interventions

PROCEDUREDialysis during 4 hours

Blood and dialysate sampling

PROCEDUREDialysis during 6 hours

Blood and dialysate sampling

PROCEDUREDialysis during 8 hours

Blood and dialysate sampling

Sponsors

University Hospital, Ghent
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Includes ICU patients with lactate acidosis with acute renal failure

Design outcomes

Primary

MeasureTime frame
Toxin removalDuring dialysis

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026