Osteoarthritis
Conditions
Keywords
Arthroscopic
Brief summary
The purpose of this study is to examine the relationship between muscle activation and heart rate on joint generalized inflammation and arthritis development.
Detailed description
This study will test the hypothesis that knee trauma (as exemplified by the arthroscopy procedure) causes inflammation that alters muscle activation patterns locally and also disrupts the balance between parasympathetic-sympathetic reflexes. It is hypothesized that these factors contribute to development and progression of knee osteoarthritis.
Interventions
None listed
Sponsors
National Institute on Aging (NIA)
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age 40 or older * Potential candidate for knee arthroscopy for medial * Meniscal tear confirmed on MRI * Prior meniscal resection at least 1 year prior with a persistent knee effusion * Body mass index between 25-35 kg/m2
Exclusion criteria
* Knee injury in the 1 month before the initial study evaluation * Knee surgery within 1 year before the initial study evaluation * Pace-maker or defibrillator, 2nd or 3rd degree heart block, or other abnormal rhythms * Current diagnosis of diabetes mellitus, a fasting glucose\>100mg/dl or \>140 mg/dl 2 hour after a glucose challenge * Current diagnosis of an inflammatory condition (e.g. rheumatoid arthritis, gout, etc) * Untreated thyroid disease * Morbid obesity (body mass index \>35) * Neuropathy or nerve damage * Stroke or transient-ischemic attacks (mini-stroke) * Recent diagnosis of congestive heart failure or heart attack * Use of prednisone or chemotherapy, steroid or other joint or ant-inflammatory agents in the past 3 months * Current use of medications that influence heart rate * Cognitive impairment that limits your ability to provide informed consent * Pregnancy
Countries
United States
Outcome results
None listed