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Uremic Toxins in the Intensive Care Unit (ICU): Patients With Sepsis

Study of the Kinetics of Uremic Toxins in the ICU Patients With Acute Renal Failure, in Order to Optimize the Dialysis Dose: Patients With Sepsis/Multi-organ Failure

Status
Withdrawn
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00752245
Enrollment
0
Registered
2008-09-15
Start date
2008-07-31
Completion date
2013-10-04
Last updated
2022-12-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multi Organ Failure, Renal Failure

Keywords

ICU patients with acute renal failure with sepsis/multi-organ failure

Brief summary

Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with sepsis/multi-organ failure. The sampling of blood and dialysate will be done during dialyses with different durations (4, 6 and 8h)

Interventions

PROCEDUREDialysis during 4 hours

Blood and dialysate sampling

PROCEDUREDialysis during 6 hours

Blood and dialysate sampling

PROCEDUREDialysis during 8 hours

Blood and dialysate sampling

Sponsors

University Hospital, Ghent
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* ICU patients with sepsis/multi-organ failure with acute renal failure

Design outcomes

Primary

MeasureTime frame
Registration of toxin removal efficiencyDuring dialysis

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026