Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia Patients

A Randomized, Double-blind, Placebo-controlled Ascending Dose Study to Evaluate the Effect of APL180 on Endothelial Function in Patients With Familial Hypercholesterolemia

Status

Withdrawn

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00751608

Enrollment

Registered

2008-09-12

Start date

2006-09-30

Completion date

2009-02-28

Last updated

2016-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Familial Hypercholesterolemia

Keywords

Familial hypercholesterolemia, endothelial function, venous occlusion plethysmography, forearm blood flow, ApoAI-mimetic, endothelial dependent vasodilation

Brief summary

This study will evaluate the effect of APL180 on endothelial function measured by forearm venous occlusion plethysmography in patients with familial hypercholesterolemia.

Interventions

DRUGAPL180

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Confirmed presence of familial hypercholesterolemia * Women must be sterilized or post-menopausal

Exclusion criteria

* Smoking an average of greater than 10 cigarettes per day * History of cardiac events * Very low or high body weight * Treatment with fibrates or niacin * High blood triglyceride levels Other protocol-defined inclusion/

Design outcomes

Primary

Measure	Time frame
Change in forearm blood flow during each treatment	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026